Results 31 to 40 of about 16,613 (249)
TRPM1 promotes tumor progression in acral melanoma by activating the Ca2+/CaMKIIδ/AKT pathway
Journal of Advanced Research, 2023 Introduction: Acral melanoma is a predominant and aggressive subtype of melanoma in non-Caucasian populations. There is a lack of genotype-driven therapies for over 50% of patients.
Chi-Che Hsieh +9 more
doaj +1 more source
TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models
Molecular Therapy: OncologyDespite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP1, a
Christopher S. Hackett +14 more
doaj +1 more source
Acral melanoma: new insights into the immune and genomic landscape
Neoplasia: An International Journal for Oncology Research, 2023 Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from the sun, and, as
Larissa Anastacio DaCosta Carvalho +3 more
doaj +1 more source
Acral Pigmented Spitz Nevus That Clinically Mimicked Acral Lentiginous Malignant Melanoma [PDF]
, 2011 Pigmented Spitz nevus is a benign melanocytic skin lesion with distinct clinical features and it is frequently found on the extremities. However, it rarely occurs on acral area of the body, and such a case has not yet been fully documented.
김미리 +6 more
core +1 more source
TERT promoter mutation is uncommon in acral lentiginous melanoma
, 2017 Background Melanoma is a heterogeneous group of diseases with distinct sets of genetic changes. Recurrent and mutually exclusive C>T or CC>TT transition mutations were identified in the promoter region of the reverse transcriptase catalytic subunit
鄭永銘;郭冠廷;梁哲維;蔡佳惠;朱家瑜;廖肇裕 +1 more
core +1 more source
Adjuvant Anti-PD-1 Antibody Therapy for Advanced Melanoma: A Multicentre Study of 78 Japanese Cases
Acta Dermato-Venereologica, 2022 Anti-PD-1 antibodies (Abs) are among the optimal adjuvant therapies for melanoma at high risk of recurrence, especially BRAF wild-type melanoma, but the anti-tumour effects of anti-PD-1 Abs in the adjuvant setting for acral melanoma have not been ...
Yusuke Muto +14 more
doaj +1 more source
Frontiers in Oncology, 2022 m6A modification is one of the most important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of RNAs.
Zhanghui Yue +10 more
doaj +1 more source
Array Comparative Genomic Hybridization analysis in Canine Acral Melanoma
, 2022 openMelanomas are malignant neoplasms developing from melanocytes that have been described in human beings and in several animal species, including dogs.
MIANI, GIOVANNA
core
Hemp Cultivation and Crop Diversification: Implications for Ecosystem Services in Kentucky
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This study examines the ecosystem benefits of expanding hemp cultivation by assessing its impact on crop diversity. Using scenario‐based simulations and fixed‐effect panel regressions with county‐level data in Kentucky, we find that increased hemp acreage tends to enhance crop diversity, improving water quality and bird diversity.
Yunsun Park +4 more
wiley +1 more source
Temporary Programs, Lasting Questions: Ad Hoc Assistance in the U.S. Farm Safety Net
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Large ad hoc assistance programs have returned to U.S. farm policy since 2017, operating alongside a more developed safety net built around federally subsidized crop insurance, Title I commodity programs, and standing disaster assistance. This paper reviews the renewed use of ad hoc assistance, documents its recent scale using USDA data, and ...
Alejandro Plastina +1 more
wiley +1 more source