Results 1 to 10 of about 166,677 (165)

Acral Melanoma: A Review of Its Pathogenesis, Progression, and Management [PDF]

Biomolecules
Acral melanoma is a distinct subtype of cutaneous malignant melanoma that uniquely occurs on ultraviolet (UV)-shielded, glabrous skin of the palms, soles, and nail beds. While acral melanoma only accounts for 2–3% of all melanomas, it represents the most
Hensin Tsao, Soo Hyun Kim
exaly   +5 more sources

Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective

Dermatopathology (Basel, Switzerland), 2022
Acral melanocytic neoplasms, including acral melanocytic nevus and acral melanoma, are common melanocytic lesions in Asian populations. Both lesions occur on the volar surface of the hands and feet, and on nail units.
Sanghyun Park, Sook Jung Yun
exaly   +4 more sources

Multidisciplinary approach and treatment of acral and mucosal melanoma [PDF]

Frontiers in Oncology
Acral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has an age-adjusted incidence of approximately 1.8 cases per million individuals per year, accounting for about 2% to 3% of all melanoma cases.
Ana Fortuna, Teresa Amaral
exaly   +5 more sources

YAP Activation in Promoting Negative Durotaxis and Acral Melanoma Progression

Cells, 2022
Directed cell migration towards a softer environment is called negative durotaxis. The mechanism and pathological relevance of negative durotaxis in tumor progression still requires in-depth investigation.
Yuxing Huang, Jing Su, Jiayong Liu, Xin Yi, Fang Zhou, Jiaran Zhang, Jiaxiang Wang, Xuan Meng, Lu Si, Congying Wu   +9 more
doaj   +2 more sources

Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma. [PDF]

Cancer Med
ABSTRACT Purpose Acral melanoma (AM) is a rare melanoma subtype involving palms, soles, and nail beds. Clinical‐pathological features and survival of elderly AM patients remain insufficiently understood. This study aimed to investigate the characteristics and survival of elderly Chinese AM patients to support clinical management. Methods Consecutive AM
Yang K, Cai X, Wu J, Jiang K, Zhang W, Zhou H, Liu F, Wang Y, Liu J, Wu D.   +9 more
europepmc   +2 more sources

Immunotherapy in Acral and Mucosal Melanoma: Current Status and Future Directions

Frontiers in Immunology, 2021
Acral and mucosal melanomas are extremely rare in Caucasians; however, they are the predominant melanoma subtypes in Asians and other non-Caucasian populations.
Lu Si, Jun Guo, Lili Mao
exaly   +3 more sources

A Technique for the Generation of Mucosal and Acral Melanoma Cell Lines. [PDF]

Pigment Cell Melanoma Res
Simplified steps to establish acral or mucosal melanoma cell lines. ABSTRACT Mucosal and acral melanomas are rare subtypes of melanoma with unique clinical and biological features. A dearth of well‐established and characterized melanoma cell lines that reflect rare subtypes impedes research on these lethal diseases.
Banik I, Basu S, Wang M, Escobar AJ, Steri V, Camara Serrano JA, Phojanakong P, Pacheco NC, Tsai KK, Alvarez EA, Daud A, El-Sayed IH, Samarkina A, Xu J, Aquino JD, Xiao M, Herlyn M, Yeh I.   +17 more
europepmc   +2 more sources

Recurrence Patterns and Prognostic Factors in Sentinel Lymph Node-Negative Melanoma in a Taiwanese Cohort With Predominant Acral Melanoma. [PDF]

J Dermatol
ABSTRACT Cutaneous melanoma in Asian populations is characterized by a predominance of acral melanoma and distinct clinicopathologic features. Although sentinel lymph node biopsy (SLNB) is widely used for staging, a subset of SLN‐negative patients still develop recurrence, and evidence regarding recurrence patterns and prognostic factors in this group ...
Chang CY, Li CY, Wang TH, Tsai CH, Yang JS, Chiu YJ.   +5 more
europepmc   +2 more sources

Management of acral lentiginous melanoma: current updates and future directions

Frontiers in Oncology
Acral lentiginous melanoma is a rare subtype of melanoma generally associated with poor outcomes, even when diagnosed at an early stage. The tumor genetic profile remains poorly understood, but it is known to have a suppressed immune environment compared
Lilit Karapetyan, Michelle M Dugan
exaly   +3 more sources

Clinical features, molecular pathology, and immune microenvironmental characteristics of acral melanoma

Journal of Translational Medicine, 2022
Acral melanoma (AM) has unique biology as an aggressive subtype of melanoma. It is a common subtype of melanoma in races with darker skin tones usually diagnosed at a later stage, thereby presenting a worse prognosis compared to cutaneous melanoma.
Jianping Gui, Zhen Guo, Di Wu
doaj   +1 more source