Results 41 to 50 of about 166,677 (165)

Paediatric Melanonychia: Diagnosis and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Longitudinal melanonychia (LM) in children presents unique diagnostic and management challenges that cannot be adequately addressed by applying adult‐based criteria. Unlike in adults, there are no validated clinical, dermoscopic or histopathologic criteria for predicting nail unit melanoma in the paediatric population.
Angela J. Jiang, Erika Koh, Je‐Ho Mun, Dong‐Youn Lee, Matilde Iorizzo, Adam I. Rubin   +5 more
wiley   +1 more source

BRAF inhibitors: efficacious and tolerable in BRAF-mutant acral and mucosal melanoma

, 2017
BRAF inhibitors substantially have impressive clinical efficacy in cutaneous melanoma. However, their role in acral and mucosal melanoma remains unclear.
C. L. CUI, X. WANG, Y. KONG, Mao, L. L., Z. H. CHI, Bai, X., Guo, J., Dai, J., X. N. SHENG, L. L. MAO, L. SI, Tang, B. X., Li, S. M., L. ZHOU, Wang, X., Lian, B., Sheng, X. N., Gui, C. L., X. Q. YAN, B. LIAN, Yan, X. Q., Chi, Z. H., X. BAI, Kong, Y., Zhou, L., S. M. LI, J. DAI, Si, L., B. X. TANG, J. GUO   +29 more
core   +1 more source

The Effects of an Educational Video on Patient Understanding of Amelanotic Melanoma

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Amelanotic melanoma (AM) is a subset of melanoma with little to no pigment that can masquerade as a benign condition, and is associated with delayed diagnosis, greater Breslow depth, higher tumour stage, and lower survival than pigmented melanoma.
Aria Wei, Bilal Haque, Kamil Taneja, Stephanie Savory   +3 more
wiley   +1 more source

Adjuvant Anti-PD-1 Immunotherapy versus Conventional Therapy for Stage III Melanoma: A Real-World Retrospective Cohort Study

Pharmaceuticals, 2022
The use of adjuvant therapy has provided survival benefits in patients with advanced melanoma. This study aimed to explore the recurrence and prognosis of the PD-1 inhibitor, conventional interferon (IFN), or observation (OBS) on resected stage III acral
Tong Li, Yu Xu, Wei Sun, Wangjun Yan, Chunmeng Wang, Tu Hu, Xiaowei Zhang, Zhiguo Luo, Xin Liu, Yong Chen   +9 more
doaj   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, EarlyView.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Parallel ridge pattern on dermoscopy: observation in non-melanoma cases [PDF]

Anais Brasileiros de Dermatologia, 2013
The acral melanoma is the most prevalent type of melanoma in the non-Caucasian population, and dermoscopy is a useful tool for earlier diagnosis and differentiation from benign lesions.
Tainá Scalfoni Fracaroli, Fernanda Guedes Lavorato, Juan Piñeiro Maceira, Carlos Barcaui   +3 more
doaj   +1 more source

Diagnostic Utility of PRAME Immunohistochemistry for Distinguishing Acral Melanoma From Acral Melanocytic Nevi

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Introduction Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry helps distinguish non‐acral melanocytic lesions, but few studies have addressed its value in acral lesions. We aimed to identify an optimal PRAME cut‐off score to differentiate acral melanoma (AM) from acral melanocytic nevi (AMN).
Kritsada Phatcharamaneepakorn, Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Manasmon Chairatchaneeboon, Nutcha Yodrabum   +4 more
wiley   +1 more source

Acral melanoma detection using a convolutional neural network for dermoscopy images. [PDF]

PLoS ONE, 2018
Acral melanoma is the most common type of melanoma in Asians, and usually results in a poor prognosis due to late diagnosis. We applied a convolutional neural network to dermoscopy images of acral melanoma and benign nevi on the hands and feet and ...
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh   +6 more
doaj   +1 more source

Overall Survival of Patients With Unresectable or Metastatic BRAF V600-Mutant Acral/Cutaneous Melanoma Administered Dabrafenib Plus Trametinib: Long-Term Follow-Up of a Multicenter, Single-Arm Phase IIa Trial

Frontiers in Oncology, 2021
ObjectivesTo examine the long-term survival outcome of dabrafenib in combination with trametinib in Chinese patients with unresectable or metastatic acral/cutaneous melanoma with BRAF-V600 mutation and to explore potential predictors of effectiveness ...
Lili Mao, Ya Ding, Xue Bai, Xinan Sheng, Jie Dai, Zhihong Chi, Chuanliang Cui, Yan Kong, Yun Fan, Yanjun Xu, Xuan Wang, Bixia Tang, Bin Lian, Xieqiao Yan, Siming Li, Li Zhou, Xiaoting Wei, Caili Li, Jun Guo, Xiaoshi Zhang, Lu Si   +20 more
doaj   +1 more source

Enhanced Melan‐A Red Chromogen Labeling in Melanoma Compared to Nevus Cells: A Diagnostic Aid in Dual Multiplex Immunohistochemistry With Ki67

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Distinguishing melanoma cells from nevus cells remains a diagnostic challenge, particularly in cases where melanoma exhibits nevoid morphology or nevus cells display atypical or epithelioid features. Accurate identification is essential for proper measurement of Breslow depth in melanomas arising in association with nevi and for ...
Peter N. Kundert, Elsayed H. Ibrahim, Victor G. Prieto, Phyu P. Aung   +3 more
wiley   +1 more source