Results 211 to 220 of about 5,566 (287)

Inverse conjugate additions of acrylic amides and esters with F/Cl/O/N-nucleophiles and CF₃⁺ reagents. [PDF]

Sci Adv
Liu X, Kou Y, Wu H, Liu TX, Liu Q, Zhang Z, Zhang X, Zhang G.   +7 more
europepmc   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening. [PDF]

ACS Med Chem Lett
Szalai TV, di Lorenzo V, Péczka N, Mihalovits LM, Petri L, Ashraf QF, de Araujo ED, Honti V, Bajusz D, Keserű GM.   +9 more
europepmc   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

Complete Imaging Resolution of Ductal Carcinoma In Situ During Osimertinib Therapy for Synchronous EGFR Exon 19-Mutant Non-Small Cell Lung Cancer: A Case Report. [PDF]

Int J Mol Sci
Assad Maia Sandoval L, Sharpe RE, Fullenkamp AJ, Downs E, Mina L.   +4 more
europepmc   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Rescue of Suprasellar Metastasis of <i>EGFR</i>-mutant NSCLC by Daily Osimertinib Re-escalation With Filgrastim Support. [PDF]

In Vivo
Saito S, Matsuda S, Nakamura M, Takahashi R, Yamamoto R, Ibe M, Takamori M, Kitazono M.   +7 more
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Oxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers. [PDF]

Angew Chem Int Ed Engl
Levkovsky IO, Trachsel L, Murata H, Matyjaszewski K.   +3 more
europepmc   +1 more source

Controlling Structures and Properties of NaCl‐Containing Alginate/Polyacrylamide Tough Hydrogels via a One‐Pot Process

Chemistry – A European Journal, EarlyView.
NaCl‐incorporated alginate/polyacrylamide tough hydrogels are prepared through a facile one‐pot strategy that enables direct ion incorporation during network formation. Compared with conventional soaking, this approach reduces diffusion‐limited ion gradients and provides a more spatially consistent ion distribution.
Taeuk Eom, Hyunseung Kim, Jihun Choi, Soon Joo Yoon, Yoon Kyeung Lee, Kwi‐Il Park, Chang Kyu Jeong   +6 more
wiley   +1 more source