Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches [PDF]
Ecology and EvolutionUnderstanding the adaptive evolution of brain function in extreme environments remains a central challenge in evolutionary biology. This study investigates the molecular mechanisms underlying cave adaptation by comparing brain transcriptomes of sympatric
Chunqing Li +4 more
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An experimental Study using ACSL and Frama-C to formulate and verify Low-Level Requirements from a DO-178C compliant Avionics Project [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Safety critical avionics software is a natural application area for formal verification. This is reflected in the formal method's inclusion into the certification guideline DO-178C and its formal methods supplement DO-333.
Frank Dordowsky
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Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets [PDF]
Molecular BiomedicineThe long-chain acyl-CoA synthetase (ACSL) family comprises key enzymes that are integral to the fatty acid metabolic pathway and play crucial roles in governing fatty acid (FA) metabolism and lipid homeostasis.
Xiaoliang Deng +3 more
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Combining ACSL Specifications and Machine Code [PDF]
Труды Института системного программирования РАН, 2018 When developing programs in high-level languages, developers have to make assumptions about the correctness of the compiler. However, this may be unacceptable for critical systems.
P. A. Putro
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Involvement of ACSL3 in the formation of autophagosomes and lipid droplets during starvation conditions [PDF]
Autophagy ReportsAcyl-CoA synthetase long-chain (ACSL) catalyzes the conversion of fatty acids into acyl-CoA, which is used for neutral lipid and phospholipid synthesis.
Shun Kato, Mitsuo Tagaya
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miRNA-541-5p regulates myocardial ischemia–reperfusion injury by targeting ferroptosis [PDF]
Journal of Cardiothoracic SurgeryBackground This article aims to use high-throughput sequencing to identify miRNAs associated with ferroptosis in myocardial ischemia–reperfusion injury, select a target miRNA, and investigate its role in H9C2 cells hypoxia-reoxygenation injury.
ZhiYu Zhao +3 more
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ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis [PDF]
Frontiers in PharmacologyLipid peroxidation stands as a prominent hallmark and a prerequisite for the onset of ferroptosis. Lipid metabolism holds a pivotal role in regulating this process, forming the metabolic foundation for cellular sensitivity to ferroptosis.
Yulang Jiang +8 more
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Bioinformatics insights into ACSL1 and ACSL5: prognostic and immune roles in low-grade glioma [PDF]
BMC CancerBackground Fatty acid metabolism disruptions affect low-grade gliomas (LGGs), with glioma cells depending on fatty acids for survival. Targeting fatty acid oxidation through the acyl-coenzyme A synthetase long-chain (ACSL) family could alleviate glioma ...
Cheng Zhang +4 more
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Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction [PDF]
Molecular OncologyMultiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression; however, the underlying mechanisms remain unclear.
Connor S. Murphy +12 more
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A study on the microbiome within oropharyngeal cancer tissues [PDF]
Discover OncologyOropharyngeal cancer (OPC), a prevalent head and neck malignancy, is witnessing a rise in incidence and mortality rates annually. Our study aimed to understand the microbial composition within OPC tissue, utilizing the 2bRAD-M technique to analyze ...
Ran Sun +8 more
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