Results 51 to 60 of about 5,780 (194)

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Modeling the Transition From Decompensated to Pathological Hypertrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundLong‐chain acyl‐CoA synthetases (ACSL) catalyze the conversion of long‐chain fatty acids to fatty acyl‐CoAs. Cardiac‐specific ACSL1 temporal knockout at 2 months results in a shift from FA oxidation toward glycolysis that promotes mTORC1 ...
Florencia Pascual, Jonathan C. Schisler, Trisha J. Grevengoed, Monte S. Willis, Rosalind A. Coleman   +4 more
doaj   +1 more source

ACSL3 Promotes Hepatocellular Carcinoma Tumorigenesis and Correlates With JAK–STAT3 Signaling

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapies. Reprogrammed lipid metabolism, driven by upregulated de novo lipogenesis, is a key tumorigenic mechanism. The enzyme ACSL3 is strongly correlated with poor HCC prognosis, positioning it as a potential therapeutic target.
Melika Amelimojarad, Mandana Amelimojarad, Alireza Pourmahdian, Zhang Lu   +3 more
wiley   +1 more source

Adair County Sanitary Landfill and Recycling Center, Independent Auditor's Reports, Financial Statement and Required Supplementary Information, Schedule of Findings, June 30, 2005 [PDF]

, 2005
Other Audit Reports - 28E ...

core  

A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis

Glia, Volume 74, Issue 2, February 2026.
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil, Marina R. Hanna, Vivian Gama   +2 more
wiley   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Chunyu Zhang, Tongguo Shi   +4 more
wiley   +1 more source

Chinese Scientific Literature Annotation Method Based on Large Language Model [PDF]

Jisuanji gongcheng
High-quality annotated data are crucial for Natural Language Processing(NLP) tasks in the field of Chinese scientific literature. A method of annotation based on a Large Language Model(LLM) was proposed to address the lack of high-quality annotated ...
YANG Dongju, HUANG Juntao
doaj   +1 more source

Deductive Verification of Unmodified Linux Kernel Library Functions

, 2018
This paper presents results from the development and evaluation of a deductive verification benchmark consisting of 26 unmodified Linux kernel library functions implementing conventional memory and string operations.
B Jacobs, C Dross, F Kirchner, J-C Filliâtre, MU Mandrykin, MU Mandrykin, N Carvalho   +6 more
core   +1 more source