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ACTH precursors characterize the ectopic ACTH syndrome
Clinical Endocrinology, 1994SummaryOBJECTIVE ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro‐ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non‐pituitary tumours, but the predominant circulating form of proopiomelano‐cortin‐related peptides remains unclear.PATIENTS Fifteen patients with ...
Stewart, P. M. +9 more
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ACTH-Secreting Pheochromocytoma with False-Negative ACTH Immunohistochemistry
Endocrine Pathology, 2012Since 1955, when Roux published the first association between pheochromocytoma and Cushing’s syndrome, we have come to appreciate the unique features of this unusual clinical entity. Pheochromocytoma represents a rare cause of hypercortisolism, accounting for less than 5 % of ectopic Cushing’s syndrome while less than 1 % of pheochromocytomas is ...
M. F. Cassarino +6 more
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The assay of ACTH and the action of ACTH and steroids on corticosteroidogenesis in the mouse
Pfl�gers Archiv European Journal of Physiology, 1969The optimum conditions are described for the assay of ACTH by its steroidogenic action on mouse adrenal glands. The index of precision averaged 0.10 and the assay can detect 1 imu ACTH/ml. High concentrations of β-oestradiol, testosterone, and corticosterone inhibited adrenal steroidogenesis acting at a site prior to the formation of pregnenolone. ACTH
R J, Purrott, M, Sage
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ACTH, LPH AND RELATED PEPTIDES IN THE ECTOPIC ACTH SYNDROME
Clinical Endocrinology, 1980SUMMARYAdrenocorticotrophin. lipotrophin and the related peptides α‐MSH, CLIP, β‐endorphin and met‐enkephalin have been measured, and characterized chromatographically in tumour extracts from seven patients with the ectopic ACTH syndrome. Four of the seven tumours contained the complete family of peptides, although the proportion of one to another ...
P T, Pullan +5 more
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Studies of ACTH Antibodies and Their Reactions with Inactive Analogues of ACTH
Endocrinology, 1966It has been possible to produce neutralizing antibodies to human ACTH, porcine ACTH and synthetic α1–24ACTH. These antibodies are gamma globulins. Their in vitro reaction with ACTH does not require complement. Neutralization of ACTH occurs at both 4 and 37 C. The antibody-ACTH complexes are acid dissociable.
N, Fleischer +4 more
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