Results 71 to 80 of about 71,688 (285)

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Adrenal function during long‐term ACTH therapy for patients with developmental and epileptic encephalopathy

Epilepsia Open, 2022
Some patients with developmental and epileptic encephalopathy (DEE) respond to adrenocorticotropic hormone (ACTH) therapy but relapse soon after. While long‐term ACTH therapy (LT‐ACTH) has been attempted for these patients, no previous studies have ...
Yuki Ueda, Shuta Fujishige, Takeru Goto, Shuhei Kimura, Noriko Namatame, Masashi Narugami, Sachiko Nakakubo, Midori Nakajima, Kiyoshi Egawa, Naoya Kaneko, Kanako Nakayama, Nozomi Hishimura, Takeshi Yamaguchi, Akie Nakamura, Hideaki Shiraishi   +14 more
doaj   +1 more source

Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel

, 2011
Andrew S Bomback1, James A Tumlin2, Joel Baranski3, James E Bourdeau4, Anatole Besarab5, Alice S Appel1, Jai Radhakrishnan1, Gerald B Appel11Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York,
null Bomback, James Tumlin, Joel Baranski, James Bourdeau, Anatole Besarab, Alice Appel, null Radhakrishnan, null Appel, et al, James A Tumlin, Andrew S Bomback   +10 more
core   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Ectopiás ACTH-termelő neuroendokrin daganat = Ectopic ACTH-secreting neuroendocrine tumor [PDF]

, 2011
A szerzők súlyos hypercortisolismussal, hypokalaemiával, diabetes mellitusszal és osteoporosissal járó ectopiás ACTH-szindrómás esetüket ismertetik. Az ACTH-elválasztó tumorszövet a tüdőben helyezkedett el, amelynek szegmentális eltávolítását követő ...
Rácz, Károly, Szabó, Attila, Kiss, Róbert, Ibolya Varga, Péter Igaz, Róbert Kiss, Károly Rácz, Igaz, Péter, Lakatos, Gergely, Attila Szabó, Varga, Ibolya, Gergely Lakatos   +11 more
core   +1 more source

Fast sleep spindles as a potential prognostic marker of developmental outcome in infantile epileptic spasms syndrome

Epilepsia Open, EarlyView.
Abstract Objective The presence or absence of sleep spindles in patients with infantile epileptic spasms syndrome (IESS) has been proposed as a potential predictor of cognitive outcome; however, the validity of this predictor remains uncertain.
Kento Ohta, Thomas Reuben, Tohru Okanishi, Go Yoshino, Tatsuo Hosoda, Kentaro Okada, Yoshihiro Maegaki   +6 more
wiley   +1 more source

Ectopic ACTH syndrome due to occult bronchial carcinoid

, 2009
we describe the case of an ectopic ACTH syndrome due to occult bronchial ...
SIMONETTI, GIOVANNI MARIA EGISTO, Rufini,V, Rufini, Vittoria, Pontecorvi,A, Paragliola,RM, Pontecorvi, Alfredo, Fintini, Danilo, Paragliola, Rosa Maria, Corsello,SM, Lovicu,RM, Corsello, Salvatore Maria, Fintini,D, Simonetti,G   +12 more
core   +1 more source

Serumproteinbindung von ACTH [PDF]

, 1968
3H- 1–23-Corticotropin wurde an Dextrangel (Sephadex G-25) gebunden und konnte durch Serumproteine, Albumin oder 0,1 N HCl eluiert werden. Mittels Dextrangelfiltration wurde gefunden, daß3H-ACTH kompetitiv an Serumproteine (Albumin) und Dextrangel ...
Schwarz, K., Scriba, Peter Christian, Werder, Klaus von   +2 more
core   +1 more source

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial

Endocrine Connections
Background: 3,4-Methylenedioxymethamphetamine (MDMA), a psychoactive substance, has been proposed as a novel provocation test for oxytocin deficiency. Limited evidence suggests that MDMA may also stimulate the anterior pituitary. Therefore, this analysis
Cihan Atila, Sara-Jessica Camerin, Matthias E Liechti, Mirjam Christ-Crain   +3 more
doaj   +1 more source