Results 121 to 130 of about 794,065 (308)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Nanoscale Architecture of the Cortical Actin Cytoskeleton in Embryonic Stem Cells
Cell Reports, 2019 Summary: Mechanical cues influence pluripotent stem cell differentiation, but the underlying mechanisms are not well understood. Mouse embryonic stem cells (mESCs) exhibit unusual cytomechanical properties, including low cell stiffness and attenuated ...
Shumin Xia +7 more
doaj +1 more source
Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway. [PDF]
Onco Targets Ther, 2021 Fan S, Yan S, Yang Y, Shang J, Hao M.
europepmc +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Actin-like protein 6A/MYC/CDK2 axis confers high proliferative activity in triple-negative breast cancer. [PDF]
J Exp Clin Cancer Res, 2021 Jian Y +11 more
europepmc +1 more source
An actin-like protein is a component of axonemes from Chlamydomonas flagella
Journal of Biological Chemistry, 1979 Several lines of evidence indicate that a component of axonemes from Chlamydomonas flagella is similar to actin from rabbit skeletal muscle. The polypeptide has an apparent molecular weight of 42,000 and in a pH gradient has the electrophoretic behavior of beta-actin.
G, Piperno, D J, Luck
openaire +2 more sources
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Extraction of an actin-like protein from the prokaryote Mycoplasma pneumoniae. [PDF]
Proceedings of the National Academy of Sciences, 1977 An actin-like protein has been identified in cell extracts from the prokaryote Mycoplasma pneumoniae. This protein bears a striking resemblance to actin from vertebrates: (i) the solubility of the protein during isolation is analogous to that of actin bound to myosin (soluble in high ionic strength salt solution and insoluble at low ionic strength ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Cell Reports, 2015 Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses, is a highly prevalent and penetrant risk factor for autism.
Lara J. Duffney +10 more
doaj +1 more source