Results 31 to 40 of about 794,065 (308)

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning. [PDF]

PLoS Pathogens, 2008
The autonomous parvovirus Minute Virus of Mice (MVM) induces specific changes in the cytoskeleton filaments of infected permissive cells, causing in particular the degradation of actin fibers and the generation of "actin patches." This is attributed to a
Séverine Bär, Laurent Daeffler, Jean Rommelaere, Jürg P F Nüesch   +3 more
doaj   +1 more source

SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale [PDF]

, 2014
Cytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved.
A Bagorda, A Kortholt, A Kortholt, A Para, A Shevchenko, AJ Saldanha, AT Sasaki, C Orelio, CL Chen, CL Manahan, DM Veltman, DM Veltman, DM Veltman, EC Rericha, EL de Hostos, F Friedberg, F Vazquez, G Vlahou, H Cai, H Kae, HR Bourne, I Marin, J Condeelis, J Cox, J Faix, J Riedl, J Schindelin, J Yan, JF Cote, JF Cote, JW Han, JY Kim, KF Swaney, L Bosgraaf, L Bosgraaf, L Bosgraaf, L Chen, M Affolter, M Brenner, M de la Roche, M Patel, MJ de Hoon, MK Vartiainen, MR Lee, MS Boguski, N Ibarra, N Meller, OD Weiner, R Insall, RH Insall, RJ Eddy, S Hanna, S Levi, SE Ong, SJ Allen, SL Blagg, TJ Jeon, WN van Egmond, X Xu, Y Yang, YC Wu   +60 more
core   +3 more sources

Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]

, 2017
Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi, Burlingame, Alma, Chand, Shreya, Grammatopoulos, Dimitris K., Hasdemir, Burcu, Mahajan, Shilpi, Oses-Prieto, Juan, Woolley, Michael J.   +7 more
core   +1 more source

Presence of an actin-like protein in mycelium of Neurospora crassa [PDF]

Journal of Bacteriology, 1978
Addition of ATP, CaCl2, and KCl to supernatants prepared from mycelia of Snowflake (strain 507), a morphological mutant of Neurospora crassa, results in the formation of filaments 70 nm in diameter. The "decorated" appearance of these filaments after incubation with heavy meromyosin from rabbits suggests they are actin-like.
E D, Allen, A S, Sussman
openaire   +2 more sources

Cytoplasmic actin is an extracellular insect immune factor which is secreted upon immune challenge and mediates phagocytosis and direct killing of bacteria, and is a Plasmodium Antagonist. [PDF]

PLoS Pathogens, 2015
Actin is a highly versatile, abundant, and conserved protein, with functions in a variety of intracellular processes. Here, we describe a novel role for insect cytoplasmic actin as an extracellular pathogen recognition factor that mediates antibacterial ...
Simone L Sandiford, Yuemei Dong, Andrew Pike, Benjamin J Blumberg, Ana C Bahia, George Dimopoulos   +5 more
doaj   +1 more source

Isolation and characterization of actin‐like protein from yeast Saccharomyces Cerevisiae [PDF]

FEBS Letters, 1979
The cytoplasm of eukaryotic cells contains 5-7 nm wide micro~laments identified for 60 cell types as actin filaments by their specific ability to bind heavy meromyosin [l-4]. Actin has been isolated from > IS cell types I4 J. It accounts for 20-30% of the total protein in actively motile cells such as amoebae or blood platelets and l-2% of total ...
Koteliansky, V.E., Glukhova, M.A., Bejanian, M.V., Surguchov, A.P., Smirnov, V.N.   +4 more
openaire   +2 more sources

The MERS-CoV N Protein Regulates Host Cytokinesis and Protein Translation via Interaction With EF1A

Frontiers in Microbiology, 2021
Middle East respiratory syndrome coronavirus (MERS-CoV), a pathogen causing severe respiratory disease in humans that emerged in June 2012, is a novel beta coronavirus similar to severe acute respiratory syndrome coronavirus (SARS-CoV).
Lin Zhu, Lin Zhu, Ting Gao, Yangbo Fu, Xiujing Han, Junjie Yue, Yaoning Liu, Hainan Liu, Qincai Dong, Weihong Yang, Yong Hu, Yanwen Jin, Ping Li, Xuan Liu, Cheng Cao   +14 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

Actin‐like protein of the cytoplasm in the chromatin of Dictyostelium discoideum [PDF]

FEBS Letters, 1979
The cellular slime mould, Dictyostelium discoideum, is an attractive eukaryotic microorganism for studies on cellular development and differential gene expression [ 11. The genome has a low complexity, only 7 times that of Escherichia coli [2]. A large fraction of the chromatin is active as template [3] and the developmental cycle is determined, at ...
Weiss, Elisabeth H., Braun, Volkmar
openaire   +3 more sources