Results 51 to 60 of about 794,065 (308)
eLife, 2023 Dendrite morphogenesis is essential for neural circuit formation, yet the molecular mechanisms underlying complex dendrite branching remain elusive. Previous studies on the highly branched Caenorhabditis elegans PVD sensory neuron identified a membrane ...
Daniel A Kramer +7 more
doaj +1 more source
Calcium signalling links MYC to NUAK1 [PDF]
, 2018 NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A, +5 more
core +1 more source
The actin-like MreB proteins in Bacillus subtilis a new turn
Frontiers in Bioscience, 2012 A decade ago, two breakthrough descriptions were reported: 1) the first helix-like protein localization pattern of MreB and its paralog Mbl in Bacillus subtilis and 2) the crystal structure of Thermotoga maritima MreB1, which was remarkably similar to that of actin.
Chastanet, Arnaud +1 more
openaire +4 more sources
Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium [PDF]
, 2011 Background: Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process ...
Chambers, Karen F. +6 more
core +4 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
Actin and Bacterial Actin-Like Proteins: Insights Into Evolution [PDF]
Biophysical Journal, 2010 Protein polymers are ubiquitous in biology, from cytoskeletal filaments to bacterial pili, and in many cases contain most of the protein in the cell. While it has been assumed that each polymer has a defined structure, we can show that many polymers exist in a multiplicity of states. Conserved subunits, such as bacterial flagellin or Type IV pilin, can
openaire +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Kinetic trapping organizes actin filaments within liquid-like protein droplets
Nature CommunicationsSeveral actin-binding proteins (ABPs) phase separate to form condensates capable of curating the actin network shapes. Here, we use computational modeling to understand the principles of actin network organization within VASP condensate droplets.
Aravind Chandrasekaran +3 more
doaj +1 more source
Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]
, 1975 An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core +2 more sources