Results 131 to 140 of about 625,356 (301)

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Tropomyosin – master regulator of actin filament function in the cytoskeleton

Journal of Cell Science, 2015
Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to-tail polymer along the length of actin filaments.
P. Gunning, E. Hardeman, P. Lappalainen, Daniel P. Mulvihill   +3 more
semanticscholar   +1 more source

Alteration in actin cytoskeleton.

, 2014
The actin cytoskeleton change was determined by staining with alex488 conjugated phalloidin (green). Phalloidin binds to F-actin. The nucleus and parasite was stained with DAPI (blue) and visualized by confocal microscopy.
Koushik Roy (193484), Gopal Chakrabarti (433156), Syamal Roy (58353), Dipanwita Das Mukherjee (669295), Moumita Ghosh (344206), Kingshuk Roy Choudhury (284725)   +5 more
core   +1 more source

Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications

Advanced Materials Interfaces, EarlyView.
Graphene layers are fabricated on Cu foil and transferred onto glass substrates to form double‐ and multi‐layer G‐glass. Raman spectroscopy confirms structural integrity, while SEM and fluorescence microscopy reveal favorable adhesion and spreading of L‐929 fibroblast cells.
Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei   +8 more
wiley   +1 more source

Actin Out: Regulation of the Synaptic Cytoskeleton

Journal of Biological Chemistry, 2015
The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments.
Erin F. Spence, S. Soderling
semanticscholar   +1 more source

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

Actin cytoskeleton regulates Hippo signaling. [PDF]

, 2013
Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear.
Aaron J. W. Hsueh, Pradeep Reddy, Masashi Deguchi, Yuan Cheng, Aaron J W Hsueh, Deguchi Masashi, Reddy Pradeep, Hsueh Aaron J. W., Cheng Yuan   +8 more
core   +1 more source

In‐House Manufacturing of 3D ECM Culture Chips via Vacuum Thermoforming for Enhanced Imaging Applications

Advanced Materials Technologies, EarlyView.
Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina, Adam Tam, Jennifer Lam, Nila C. Wu, Nancy T. Li, Alison P. McGuigan   +5 more
wiley   +1 more source

LIM Proteins in Actin Cytoskeleton Mechanoresponse

Trends in Cell Biology, 2014
The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration.
Magaret J. Smith, Laura M. Hoffman, MC Beckerle   +2 more
semanticscholar   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source