Results 131 to 140 of about 860,471 (297)
Scientific ReportsBackground Long-acting pre-exposure prophylaxis (LA-PrEP) is approved in Europe with promising HIV prevention potential. Currently, no data are available that examine intention to use LA-PrEP intention when it is not fully covered by healthcare/insurance
Haoyi Wang +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Early Childhood Systems Building from a Community Perspective [PDF]
, 2010 Even when children and their families have access to support services from a variety of programs and organizations -- such as early learning centers, nutrition programs, and pediatric, nursing, dental and mental health care providers -- there are ...
Julia Coffman, Susan Parker
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Act or Revolution? Yes, Please! [PDF]
, 2013 In the context of the current crisis of global capitalism, it is crucial to determine what is the state of Marxism. Certainly, it is true that in recent decades Marxism has suffered a notable series of attacks, but in no way may we conclude that for this
Roggerone, Santiago Martín
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Silence, Rebellion, and Acting-Out of a Silenced Past: Understanding the French Riots From a Postcolonial and Transcultural Perspective. [PDF]
Front Psychiatry, 2019 Mansouri M +5 more
europepmc +1 more source
Veiling and unveiling: Mansfield's modernist aesthetics [PDF]
, 2013 The wearing of a veil like other fashionable items of attire in Mansfield’s fiction ‒ parasols, hats, gloves, muffs, and hair ribbons ‒ usually serves more than mere decoration, protection or fashion.
Wilson, Janet M
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source