Results 151 to 160 of about 4,474,712 (293)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hydroxysafflor Yellow A Reduced Neuroinflammation Induced by Astrocyte-Derived IL-17A by Inhibiting the IL-17RA/ACT1/NF-κB/IL-17A Loop After OGD/R

Journal of Inflammation Research
Lijuan Song,1,2,* Jianlin Hua,2,3,* Kexin Liu,2 Yanzhe Duan,2 Yukang Sun,2 Jiezhong Yu,1,4 Jinzhu Yin,2,3,5 Cungen Ma,1,2 Baoguo Xiao,2,6 Dong Ma,2,3,5 Jianjun Huang2– 4 1Shanxi Key Laboratory of Innovative Drug for the Treatment of ...
Song L, Hua J, Liu K, Duan Y, Sun Y, Yu J, Yin J, Ma C, Xiao B, Ma D, Huang J   +10 more
doaj  

Investigating the relationship between emotional labor levels, job satisfaction, and burnout among nurse academicians: a structural equation modeling approach. [PDF]

Front Psychol
Barış Eren N, Dinç L.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Letter to the editor: Addressing the blind spot of self-reported adherence in the era of long-acting PrEP. [PDF]

Euro Surveill
Brunoro R, Mengato D, Barbaro F, Calandrino L, Cattelan AM, Venturini F.   +5 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

KBG Syndrome: A Case Report and Longitudinal Assessment of Long-Acting Recombinant Human Growth Hormone Therapy. [PDF]

Clin Case Rep
Nan H, Zhang P, Qian J.
europepmc   +1 more source

Auditioning for empathy:dance, acting, and psychology students [PDF]

, 2018
Jola, Corinne, Lippi, D., Luciani, R., Schmidt, I.   +3 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hypoglycemia Beliefs, Impaired Hypoglycemia Awareness, and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes: Insights From CGM Users. [PDF]

Diabetes Care
Lin YK, Tang H, Ye W, Ratzki-Leewing A, Lee J, de Zoysa N, Amiel SA, Herman WH.   +7 more
europepmc   +1 more source