Results 71 to 80 of about 10,411 (204)

Streptococcus pluranimalium 2N12 Exerts an Antagonistic Effect Against the Swine Pathogen Actinobacillus pleuropneumoniae by Producing Hydrogen Peroxide

Frontiers in Veterinary Science, 2021
Actinobacillus pleuropneumoniae is the causal agent of porcine pleuropneumonia, a highly contagious and often deadly respiratory disease that causes major economic losses in the swine industry worldwide.
Katy Vaillancourt, Michel Frenette, Michel Frenette, Marcelo Gottschalk, Marcelo Gottschalk, Daniel Grenier, Daniel Grenier   +6 more
doaj   +1 more source

Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 318-339, July 2025.
ABSTRACT This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were used to assess bacterial growth and killing rates at varying ...
Andrew Mead, Abigail Hughes, Stefano Azzariti, Pierre‐Louis Toutain, Ludovic Pelligand   +4 more
wiley   +1 more source

Microarray-based comparative genomic profiling of reference strains and selected Canadian field isolates of Actinobacillus pleuropneumoniae

BMC Genomics, 2009
Background Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is a highly contagious respiratory pathogen that causes severe losses to the swine industry worldwide.
MacInnes Janet I, Foote Simon J, Bouevitch Anne, Deslandes Vincent, Findlay Wendy A, Gouré Julien, Coulton James W, Nash John HE, Jacques Mario   +8 more
doaj   +1 more source

Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication [PDF]

, 2015
Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available.
Beaudry, Francis, Ferreira Barbosa, Jérémy A., Gagnon, Carl A., Jacques, Mario, Labrie, Josée   +4 more
core   +2 more sources

Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 300-317, July 2025.
ABSTRACT This meta‐analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specific clinical breakpoints for the development of antimicrobial susceptibility testing of DOXY in ...
Pierre‐Louis Toutain, Alain Bousquet‐Melou, Aude A. Ferran, Béatrice B. Roques, Jérôme R. E. del Castillo, Peter Lees, Siska Croubels, Eric Bousquet, Ludovic Pelligand   +8 more
wiley   +1 more source

Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England [PDF]

, 2017
Herd health slaughter checks regularly identify enzootic pneumonia-like (EP-like) lesions and pleuritis. The aim of this paper is to determine the associations between these lesions and post-trimming carcass weight.
Brewster, V R, Maiti, H C, Nevel, A, Tucker, A W   +3 more
core   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Expansion of the diversity of dispersin scaffolds

Acta Crystallographica Section D, Volume 81, Issue 3, Page 130-146, March 2025.
Five GH20‐family dispersins were characterized for activity on aryl glycosides and poly‐β‐1,6‐linked N‐acetyl‐d‐glucosamine oligomers and three crystal structures were solved, including two complexes with bound inhibitors.Microorganisms are known to secrete copious amounts of extracellular polymeric substances (EPS) that form complex matrices around ...
Alexandra Males, Olga V. Moroz, Elena Blagova, Astrid Munch, Gustav H. Hansen, Annette H. Johansen, Lars H. Østergaard, Dorotea R. Segura, Alexander Eddenden, Anne V. Due, Martin Gudmand, Jesper Salomon, Sebastian R. Sørensen, João Paulo L. Franco Cairo, Mark Nitz, Roland A. Pache, Rebecca M. Vejborg, Sandeep Bhosale, David J. Vocadlo, Gideon J. Davies, Keith S. Wilson   +20 more
wiley   +1 more source

Whole‐Genomic Characterization of Two Different PRRSV‐1 Strains Isolated From a Single Pig

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Recent studies have demonstrated that porcine reproductive and respiratory syndrome virus 1 (PRRSV‐1) strains isolated from different farms in China have significant genomic heterogeneity, whereas strains from the same farm present a high degree of genomic similarity.
Bangjun Gong, Jiahao Shi, Hu Xu, Chao Li, Lirun Xiang, Zhenyang Guo, Jinhao Li, Siyu Zhang, Zixuan Feng, Haonan Kang, Xueli Zhang, Ziyu Song, Qian Wang, Jinmei Peng, Guohui Zhou, Chaoliang Leng, Kuan Zhao, Yan-Dong Tang, Huairan Liu, Tong-Qing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang, Nan-hua Chen   +23 more
wiley   +1 more source

Use of Subtherapeutic Tylvalosin Against Mycoplasma hyopneumoniae: Implications For Respiratory Microbiome Dysbiosis and Swine Lung Health

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Enzootic pneumonia (EP) caused by Mycoplasma hyopneumoniae (M. hyopneumoniae) has a significant impact on swine production. Subtherapeutic exposures of tylvalosin in swine, often due to inconsistent dosing in feed or water, promote antimicrobial resistance.
Leonardo Teófilo Toledo, Richard Costa Polveiro, Caio Augustus Diamantino, Gustavo Manoel Rigueira Simão, Carlos Eduardo Real Pereira, Eduardo de Freitas Costa, Maria Aparecida Scatamburlo Moreira, Fernanda Simone Marks, Orhan Sahin   +8 more
wiley   +1 more source