Results 121 to 130 of about 45,871 (227)

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Temporal analysis of two inducible human genes reveals post-transcriptional H3K4me3 deposition. [PDF]

Life Sci Alliance
Walvekar KP, Chilaka S.
europepmc   +1 more source

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

Global stabilization of the transcriptome in mitotic cells. [PDF]

EMBO J
Khalizeva E, Latifkar A, Xiang K, Bartel DP, Ly J, Cheeseman IM.   +5 more
europepmc   +1 more source

CHD4 Orchestrates Chromatin Remodeling to Activate the c‐Myc Signaling Pathway in Cancer Pathogenesis

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding, Yuhao Cao, Zihao Liu, Jingru Xie, Lingling Liu, Shanliang Sun, Xichao Yu, Zhendong Deng, Zhimin Fan, Ye Yang, Chunyan Gu   +10 more
wiley   +1 more source

First Successful Treatment Reported with Pembrolizumab in a Patient Diagnosed with Choriocarcinoma in Hungary. [PDF]

Life (Basel)
Lakatos KF, Kalmár L, Lahm E, Bíró EG, Fülöp V.   +4 more
europepmc   +1 more source

Generative Cell Division, but Not Early Nuclear Reorganization, Requires Transcriptional Reactivation During Pollen Tube Growth

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Bicellular pollen often enters a desiccated state wherein development is temporarily arrested, enabling long‐term survival while maintaining the capacity for rapid activation upon hydration. Although the generative cell in mature pollen of Lilium species is known to have completed DNA replication, its precise cell‐cycle status and the ...
Mio K. Shibuta, Aina Komatsu, Tsugumi Aso   +2 more
wiley   +1 more source

Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis

International Journal of Rheumatic Diseases, Volume 29, Issue 6, June 2026.
ABSTRACT Objective We investigated the role of GLI3, a transcription factor highly expressed in the pathogenic THY1+CD34− sublining subset of rheumatoid arthritis synovial fibroblasts (RASFs), in regulating their pathogenic behavior. Methods GLI3 protein levels were quantified in freshly isolated RASF subsets by Western blotting.
Motohiko Sato, Tetsuya Saito, Yoji Komiya, Seiji Noda, Yasuhiro Tagawa, Akio Yamamoto, Hideyuki Iwai, Kentaro Endo, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Eiryo Kawakami, Tadashi Hosoya, Shinsuke Yasuda   +14 more
wiley   +1 more source

Exploitation of actinomycetes from coastal ecosystems of İzmir Peninsula for antimicrobial activity via strain identification, untargeted metabolomics and drug combination studies. [PDF]

Microb Cell Fact
Kurt MÜ, Can Ö, Karakuzu B, Üner G, Gören AC, Uzel A, Bedir E.   +6 more
europepmc   +1 more source

GPSM2 Promotes Pancreatic Cancer Progression Through METTL3‐Mediated m6A Modification of YAP1 mRNA

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer poses a major therapeutic challenge due to its insidious onset and difficulty in early diagnosis. G‐protein signalling modulator 2 (GPSM2), a member of the G‐protein signalling regulator family, is highly expressed in various tumour tissues; however, its role in pancreatic cancer remains largely undefined.
Jiajun Xiu, Li Qiao, Miaomiao Li, Xiaoan Hu, Zixuan Shen, Rui Yang, Hairu Zhang, Zhe Dong, Xuelei Liu, Yinghui Zhang   +9 more
wiley   +1 more source