Results 41 to 50 of about 20,440,250 (309)

ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players

International Journal of Molecular Sciences, 2016
The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive response,
Entaz Bahar, Hyongsuk Kim, Hyonok Yoon
semanticscholar   +1 more source

Distinctive Properties and Powerful Neuromodulation of Na_v1.6 Sodium Channels Regulates Neuronal Excitability

Cells, 2021
Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Nav1.6 is highly enriched at the axon
Agnes Zybura, Andy Hudmon, Theodore R. Cummins   +2 more
doaj   +1 more source

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

PLoS Comput. Biol., 2011
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia mechanisms, are usually performed with channels expressed in non myocytes, or with non-human myocytes. Differences between cell types and species affect results. Thus,
Thomas O'Hara, L. Virág, A. Varró, Y. Rudy   +3 more
semanticscholar   +1 more source

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Frontiers in Pharmacology, 2020
Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic ...
B. Salehi, Javad Sharifi‐Rad, Francesca Cappellini, Ž. Reiner, Debora Zorzan, M. Imran, B. Şener, M. Kılıç, M. El‐Shazly, Nouran M. Fahmy, Eman Al‐Sayed, M. Martorell, C. Tonelli, K. Petroni, A. Docea, D. Calina, A. Maroyi   +16 more
semanticscholar   +1 more source

Neurocomputational mechanisms underlying perception and sentience in the neocortex

Frontiers in Computational Neuroscience
The basis for computation in the brain is the quantum threshold of “soliton,” which accompanies the ion changes of the action potential, and the refractory membrane at convergences.
Andrew S. Johnson, William Winlow, William Winlow   +2 more
doaj   +1 more source

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

Computation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

The Tachyon Potential in Open Neveu-Schwarz String Field Theory [PDF]

, 2000
A classical action for open superstring field theory has been proposed which does not suffer from contact term problems. After generalizing this action to include the non-GSO projected states of the Neveu-Schwarz string, the pure tachyon contribution to ...
Berkovits, Nathan
core   +4 more sources

Action potential broadening in a presynaptic channelopathy

Nature Communications, 2016
Brain development and interictal function are unaffected in many paroxysmal neurological channelopathies, possibly explained by homoeostatic plasticity of synaptic transmission.
Rahima Begum, Y. Bakiri, K. Volynski, D. Kullmann   +3 more
semanticscholar   +1 more source

Biocytin-Labeling in Whole-Cell Recording: Electrophysiological and Morphological Properties of Pyramidal Neurons in CYLD-Deficient Mice

Molecules, 2023
Biocytin, a chemical compound that is an amide formed from the vitamin biotin and the amino acid L-lysine, has been used as a histological dye to stain nerve cells.
Shuyi Tan, Xiuping Mo, Huihui Qin, Binbin Dong, Jiankui Zhou, Cheng Long, Li Yang   +6 more
doaj   +1 more source

Rapid genetic algorithm optimization of a mouse computational model: Benefits for anthropomorphization of neonatal mouse cardiomyocytes

Frontiers in Physiology, 2012
While the mouse presents an invaluable experimental model organism in biology, its usefulness in cardiac arrhythmia research is limited in some aspects due to major electrophysiological differences between murine and human action potentials (APs).
Corina Teodora Bot, Armen R. Kherlopian, Armen R. Kherlopian, Francis A. Ortega, David J. Christini, David J. Christini, Trine eKrogh-Madsen, Trine eKrogh-Madsen, Trine eKrogh-Madsen   +8 more
doaj   +1 more source