Results 21 to 30 of about 13,026,798 (304)

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

Neural Regeneration Research, 2015
Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by ...
Ting-ting Hou, Xiao-yu Yang, Peng Xia, Su Pan, Jian Liu, Zhi-ping Qi   +5 more
doaj   +1 more source

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E₂

Cells, 2020
Motor neuron diseases are a group of progressive neurological disorders that degenerate motor neurons. The neuroblastoma × spinal cord hybrid cell line NSC-34 is widely used as an experimental model in studies of motor neuron diseases.
Hiroshi Nango, Yasuhiro Kosuge, Masaki Sato, Yoshiyuki Shibukawa, Yuri Aono, Tadashi Saigusa, Yoshihisa Ito, Kumiko Ishige   +7 more
doaj   +1 more source

Distinctive Properties and Powerful Neuromodulation of Na_v1.6 Sodium Channels Regulates Neuronal Excitability

Cells, 2021
Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Nav1.6 is highly enriched at the axon
Agnes Zybura, Andy Hudmon, Theodore R. Cummins   +2 more
doaj   +1 more source

Neurocomputational mechanisms underlying perception and sentience in the neocortex

Frontiers in Computational Neuroscience
The basis for computation in the brain is the quantum threshold of “soliton,” which accompanies the ion changes of the action potential, and the refractory membrane at convergences.
Andrew S. Johnson, William Winlow, William Winlow   +2 more
doaj   +1 more source

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

Computation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

Biocytin-Labeling in Whole-Cell Recording: Electrophysiological and Morphological Properties of Pyramidal Neurons in CYLD-Deficient Mice

Molecules, 2023
Biocytin, a chemical compound that is an amide formed from the vitamin biotin and the amino acid L-lysine, has been used as a histological dye to stain nerve cells.
Shuyi Tan, Xiuping Mo, Huihui Qin, Binbin Dong, Jiankui Zhou, Cheng Long, Li Yang   +6 more
doaj   +1 more source

In action with action potentials

Journal of Physics: Conference Series, 2019
Abstract The subject of bioelectricity is for many life science students the first encounter with biophysics. The transfer of knowledge on electricity from the context of physics to the context of physiology is not without difficulty.
openaire   +3 more sources

Rapid genetic algorithm optimization of a mouse computational model: Benefits for anthropomorphization of neonatal mouse cardiomyocytes

Frontiers in Physiology, 2012
While the mouse presents an invaluable experimental model organism in biology, its usefulness in cardiac arrhythmia research is limited in some aspects due to major electrophysiological differences between murine and human action potentials (APs).
Corina Teodora Bot, Armen R. Kherlopian, Armen R. Kherlopian, Francis A. Ortega, David J. Christini, David J. Christini, Trine eKrogh-Madsen, Trine eKrogh-Madsen, Trine eKrogh-Madsen   +8 more
doaj   +1 more source

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp

Frontiers in Pharmacology, 2021
Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes.
Arie O. Verkerk, Arie O. Verkerk, Gerard A. Marchal, Jan G. Zegers, Makiri Kawasaki, Antoine H. G. Driessen, Carol Ann Remme, Joris R. de Groot, Ronald Wilders   +8 more
doaj   +1 more source

Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons

eLife, 2014
Synaptic inputs from different brain areas are often targeted to distinct regions of neuronal dendritic arbors. Inputs to proximal dendrites usually produce large somatic EPSPs that efficiently trigger action potential (AP) output, whereas inputs to ...
Qian Sun, Kalyan V Srinivas, Alaba Sotayo, Steven A Siegelbaum   +3 more
doaj   +1 more source