Results 21 to 30 of about 1,972,239 (254)

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

eLife, 2022
Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited this to
Amy Richardson, Victoria Ciampani, Mihai Stancu, Kseniia Bondarenko, Sherylanne Newton, Joern R Steinert, Nadia Pilati, Bruce P Graham, Conny Kopp-Scheinpflug, Ian D Forsythe   +9 more
doaj   +1 more source

In action with action potentials

Journal of Physics: Conference Series, 2019
Abstract The subject of bioelectricity is for many life science students the first encounter with biophysics. The transfer of knowledge on electricity from the context of physics to the context of physiology is not without difficulty.
openaire   +3 more sources

Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons

Biophysica, 2022
Living organisms react to external stimuli to adapt their activity to the environment for survival. Acquired information is encoded by neurons by action potentials (APs) in a series of discrete electrical events.
Daria Y Romanova, Pavel M Balaban, Evgeny S Nikitin   +2 more
doaj   +1 more source

The Impact of Stimulation Induced Short Term Synaptic Plasticity on Firing Patterns in the Globus Pallidus of the Rat

Frontiers in Systems Neuroscience, 2011
Electrical stimulation in the globus pallidus (GP) leads to complex modulations of neuronal activity in the stimulated nucleus. Multiple in-vivo studies have demonstrated the modulation of both firing rates and patterns during and immediately following ...
Jenia eBugaysen, Izhar eBar‐Gad, Alon eKorngreen   +2 more
doaj   +1 more source

Recording Neural Activity Based on Surface Plasmon Resonance by Optical Fibers-A Computational Analysis

Frontiers in Computational Neuroscience, 2018
An all optical, non-destructive method for monitoring neural activity has been proposed and its performance in detection has been analyzed computationally.
Mitra Abedini, Tahereh Tekieh, Pezhman Sasanpour, Pezhman Sasanpour   +3 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

On mathematical modeling of the propagation of a wave ensemble within an individual axon

Frontiers in Cellular Neuroscience, 2023
The long history of studying the propagation of an action potential has revealed that an electrical signal is accompanied by mechanical and thermal effects. All these effects together generate an ensemble of waves. The consistent models of such a complex
Tanel Peets, Kert Tamm, Jüri Engelbrecht, Jüri Engelbrecht   +3 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements

Frontiers in Physiology
Measurement of the ventricular action potential (AP) via whole-cell patch clamp is an important contributor to cardiac electrophysiological research. Neonatal rat ventricular cardiomyocytes (NRVCM) are a commonly used model, in particular for stressor ...
Pascal Syren, Pascal Syren, Pascal Syren, Anna Zlatopolskaia, Anna Zlatopolskaia, Anna Zlatopolskaia, Claus Bruehl, Axel Schöffel, Axel Schöffel, Axel Schöffel, Teresa Caspari, Teresa Caspari, Teresa Caspari, Chiara Heß, Chiara Heß, Chiara Heß, Norbert Frey, Norbert Frey, Norbert Frey, Dierk Thomas, Dierk Thomas, Dierk Thomas, Patrick Lugenbiel, Patrick Lugenbiel, Patrick Lugenbiel   +24 more
doaj   +1 more source

Upper Limit on the Thermodynamic Information Content of an Action Potential

Frontiers in Computational Neuroscience, 2020
In computational neuroscience, spiking neurons are often analyzed as computing devices that register bits of information, with each action potential carrying at most one bit of Shannon entropy.
Sterling Street
doaj   +1 more source