Results 11 to 20 of about 13,026,798 (304)

Emerging Roles of the Membrane Potential: Action Beyond the Action Potential [PDF]

Frontiers in Physiology, 2018
Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as
Lina Abdul Kadir, Michael Stacey, Richard Barrett-Jolley   +2 more
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Bridging the Molecular-Cellular Gap in Understanding Ion Channel Clustering

Frontiers in Pharmacology, 2020
The clustering of many voltage-dependent ion channel molecules at unique neuronal membrane sites such as axon initial segments, nodes of Ranvier, or the post-synaptic density, is an active process mediated by the interaction of ion channels with scaffold
Valerie Abigail Nirenberg, Ofer Yifrach
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Excitation and contraction of cardiac muscle and coronary arteries of brain‐dead pigs

FASEB BioAdvances, 2023
Excitability and contraction of cardiac muscle from brain‐dead donors critically influence the success of heart transplantation. Membrane physiology, Ca2+‐handling, and force production of cardiac muscle and the contractile properties of coronary ...
Per Arlock, Mei Li, Benjamin Davis, Cecilia Lövdahl, Qiuming Liao, Trygve Sjöberg, Awahan Rahman, Björn Wohlfart, Stig Steen, Anders Arner   +9 more
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Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons

Biophysica, 2022
Living organisms react to external stimuli to adapt their activity to the environment for survival. Acquired information is encoded by neurons by action potentials (APs) in a series of discrete electrical events.
Daria Y Romanova, Pavel M Balaban, Evgeny S Nikitin   +2 more
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Upper Limit on the Thermodynamic Information Content of an Action Potential

Frontiers in Computational Neuroscience, 2020
In computational neuroscience, spiking neurons are often analyzed as computing devices that register bits of information, with each action potential carrying at most one bit of Shannon entropy.
Sterling Street
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Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice

Frontiers in Cellular Neuroscience, 2021
Autism spectrum disorder (ASD) is associated with a range of abnormalities pertaining to socialization, communication, repetitive behaviors, and restricted interests. Owing to its complexity, the etiology of ASD remains incompletely understood.
Xiaona Wang, Chao Gao, Yaodong Zhang, Shunan Hu, Yidan Qiao, Zhengqin Zhao, Lingshan Gou, Jijun Song, Qi Wang   +8 more
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Essential oil composition and antinociceptive activity of Thymus capitatus

Pharmaceutical Biology, 2017
Context: The essential oil (EO) from Thymus capitatus Hoff. et Link. (Lamiaceae) has been traditionally used for its medicinal properties, such as anti-inflammatory, analgesic, antioxidant and antimicrobial properties.
Juan Carlos Ramos Gonçalves, Danilo Andrade de Meneses, Aliny Pereira de Vasconcelos, Celyane Alves Piauilino, Fernanda Regina de Castro Almeida, Edoardo Marco Napoli, Giuseppe Ruberto, Demetrius Antônio Machado de Araújo   +7 more
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The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

BioMedical Engineering OnLine, 2018
Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
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Calcineurin Aβ gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte

Open Life Sciences, 2021
It has been shown that the activation of calcineurin is involved in regulating ion channel remodeling in hypertrophic cardiomyocytes. But the precise role of calcineurin in the regulation of transient outward potassium current (I to), an ...
Yang Long, Deng Na, He Jionghong, Xia Guiling, Yang Ying, Zhao Yidong, Huo Zhaomei, Guo Chuxian   +7 more
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Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

Frontiers in Physiology, 2021
Ca2+ and Vm transitions occurring throughout action potential (AP) cycles in sinoatrial nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating within criticality (Ca2+ domain) and limit-cycle (Vm domain) mechanisms
Dongmei Yang, Christopher H. Morrell, Christopher H. Morrell, Alexey E. Lyashkov, Syevda Tagirova Sirenko, Ihor Zahanich, Yael Yaniv, Tatiana M. Vinogradova, Bruce D. Ziman, Victor A. Maltsev, Edward G. Lakatta   +10 more
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