Results 11 to 20 of about 1,972,239 (254)

Emerging Roles of the Membrane Potential: Action Beyond the Action Potential [PDF]

open access: yesFrontiers in Physiology, 2018
Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as
Lina Abdul Kadir   +2 more
doaj   +5 more sources

Artificial Action Potential and Ionic Power Device Inspired by Ion Channels and Excitable Cell

open access: yesAdvanced Science, 2023
In vivo, the membrane potential of the excitable cell working by ion gradients plays a significant role in bioelectricity generation and nervous system operation.
Jung‐Soo Kim   +4 more
doaj   +1 more source

The ‘Reverse FDUF’ Mechanism of Atrial Excitation–Contraction Coupling Sustains Calcium Alternans—A Hypothesis

open access: yesBiomolecules, 2022
Cardiac calcium alternans is defined as beat-to-beat alternations of Ca transient (CaT) amplitude and has been linked to cardiac arrhythmia, including atrial fibrillation.
Kathrin Banach, Lothar A. Blatter
doaj   +1 more source

Mechanisms of Synaptic Vesicle Exo- and Endocytosis

open access: yesBiomedicines, 2022
Within 1 millisecond of action potential arrival at presynaptic terminals voltage–gated Ca2+ channels open. The Ca2+ channels are linked to synaptic vesicles which are tethered by active zone proteins. Ca2+ entrance into the active zone triggers: (1) the
Sumiko Mochida
doaj   +1 more source

Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity

open access: yesLife, 2022
Maintaining the excitability of neurons and circuits is fundamental for healthy brain functions. The global compensatory increase in excitatory synaptic strength, in response to decreased activity, is one of the main homeostatic mechanisms responsible ...
Federica Cordella   +9 more
doaj   +1 more source

Essential oil composition and antinociceptive activity of Thymus capitatus

open access: yesPharmaceutical Biology, 2017
Context: The essential oil (EO) from Thymus capitatus Hoff. et Link. (Lamiaceae) has been traditionally used for its medicinal properties, such as anti-inflammatory, analgesic, antioxidant and antimicrobial properties.
Juan Carlos Ramos Gonçalves   +7 more
doaj   +1 more source

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

open access: yesBioMedical Engineering OnLine, 2018
Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
doaj   +1 more source

Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons

open access: yesFrontiers in Cellular Neuroscience, 2013
Fast-spiking interneurons (FSIs) play a central role in organizing the output of striatal neural circuits, yet functional interactions between these cells are still largely unknown.
Giovanni eRusso   +3 more
doaj   +1 more source

Neurocomputational mechanisms underlying perception and sentience in the neocortex

open access: yesFrontiers in Computational Neuroscience
The basis for computation in the brain is the quantum threshold of “soliton,” which accompanies the ion changes of the action potential, and the refractory membrane at convergences.
Andrew S. Johnson   +2 more
doaj   +1 more source

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

open access: yesComputation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

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