Results 131 to 140 of about 14,186,648 (294)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Protocol for a health technology assessment of extending BowelScreen to those aged 50 to 54 years
Following a request from the National Screening Advisory Committee (NSAC), HIQA has commenced work on a health technology assessment (HTA) of extending Ireland’s national colorectal cancer screening programme, BowelScreen, to those aged 50 to 54 years ...
Health Information and Quality Authority (HIQA)
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Health technology assessment of Herpes Zoster (shingles) vaccination
Herpes zoster, which is commonly known as shingles, affects approximately one in three people who have had chickenpox. Shingles is typically recognised by a painful blistering rash on the torso.
Health Information and Quality Authority (HIQA)
core
Scientific ReportsTraditional police combat training relies heavily on subjective evaluation by human instructors, which lacks consistency and comprehensive coverage of complex movement patterns in real-world scenarios. This paper presents an enhanced deep spatio-temporal
Yan Wang
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Improving quality and consistency of dissertation assessment [PDF]
During the last decade, there has been increasing calls for Higher Education to improve standards, increase the quality of assessment, and for greater accountability of lecturers.
Pathirage, C. P. +2 more
core +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FineSkiing: A Fine-grained Benchmark for Skiing Action Quality Assessment
CoRRAction Quality Assessment (AQA) aims to evaluate and score sports actions, which has attracted widespread interest in recent years. Existing AQA methods primarily predict scores based on features extracted from the entire video, resulting in limited interpretability and reliability.
Yongji Zhang, Siqi Li, Yue Gao, Yu Jiang
openaire +2 more sources