Results 121 to 130 of about 65,332 (276)

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source

How I Investigate Borderline Prolonged aPTT: An Integrated Laboratory Approach to Mixing Studies and Factor Analysis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Borderline prolongation of routine clotting assays—particularly the activated partial thromboplastin time (aPTT)—is a common interpretative challenge in laboratory hematology. These reproducible but mildly prolonged results often lie just beyond the upper reference limit and can trigger unnecessary follow‐up, delays, or misinterpretation ...
Nikolaos Androulakis, Eleni Nioti, Antonios Dilintas, Christina Kalpadakis   +3 more
wiley   +1 more source

Anaphylactic transfusion reaction to group B platelets related to alpha‐gal syndrome: A case report

Transfusion, EarlyView.
Abstract Background Alpha‐gal syndrome (AGS), a distinct form of IgE‐mediated hypersensitivity to the carbohydrate galactose‐α‐1,3‐galactose (α‐Gal), typically occurs after repeated tick bites and leads to allergic reactions after ingestion of mammalian meat.
Oscar Andre Hinojosa, Amitava Dasgupta, Zhan Ye   +2 more
wiley   +1 more source

Antiphosphatidylserine antibody as a cause of multiple dural venous sinus thromboses and ST-elevation myocardial infarction [PDF]

, 2018
Objective: Rare disease Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antibodies directed against phos-pholipids on plasma membranes. Through unclear mechanisms, APS confers hypercoagulability.
Marquardt, Caillin W., Pickens, Peter V., Varner, Chelsea K.   +2 more
core   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, EarlyView.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Infection with the Neorickettsial Organism Stellantchasmus falcatus Agent in an Arctic Fox (Vulpes lagopus)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 1‐year‐old female‐intact arctic fox (Vulpes lagopus) presented for diarrhea, lethargy, severe thrombocytopenia, and hyperbilirubinemia. Blood film evaluation revealed intracytoplasmic coccoid bacteria within moderate numbers of leukocytes consistent with infection by a rickettsial organism.
Jeremy P. Bessett, Alexis G. Davidson, Alyssa M. Scagnelli, Kristen R. Friedrichs   +3 more
wiley   +1 more source

Intravenous Administration of Vitamin K1 in Dogs and Cats Presented for Anticoagulant Rodenticide Poisoning: A Retrospective Study of 58 Cases

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To evaluate the safety of IV lecithin‐solubilizing agent‐based vitamin K1 (VK‐LSE) administration and compare the outcomes in dogs and cats with anticoagulant rodenticide (AR) poisoning that received IV VK‐LSE with or without exogenous coagulation factors (CF). Design Retrospective study (January 2010 to January 2022).
Camille Dartencet, Céline Pouzot‐Nevoret, Marine Poupon, Mark W. Kim, Bernard Allaouchiche, Alexandra Nectoux   +5 more
wiley   +1 more source

Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]

, 2000
Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston, Derom, Eric, Petrovic, Mirko   +2 more
core  

Psychological stress catalyses free radical–mediated activation of coagulation in humans

The Journal of Physiology, EarlyView.
Abstract figure legend This study provides the first in vivo evidence that acute psychological stress triggers systemic free radical formation and prothrombotic remodelling of blood clot microstructure. By inducing stress in healthy participants, we observed a significant increase in oxidative stress (A•−), a shortening of the intrinsic pathway of ...
Lewis Fall, Benjamin S. Stacey, Elsie Swain, Ebony Samuel, Meghan Robinson, Danny W. Walmsley, Christopher J. Marley, Thomas S. Owens, Adnan Haq, Leon G. Yandle, Kevin Cox, Damian M. Bailey   +11 more
wiley   +1 more source

Activated Partial Thromboplastin Time Abnormality in Patients with Cholangiocarcinoma

Clinical and Applied Thrombosis/Hemostasis, 2004
Cholangiocarcinoma can be detected worldwide, but is most common in tropical areas where crowded living conditions and poor sanitation exist. This infection can demonstrate a wide spectrum of clinical presentations from no complaints to arrest. Similar to the other liver diseases, the activated partial thromboplastin time abnormality can be seen in the
openaire   +2 more sources