Results 11 to 20 of about 49,137 (244)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients

Pakistan Armed Forces Medical Journal, 2022
Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient.
Zareen Irshad, Nazish Jaffar, Talat Zehra, Faiza Zeeshan, Sunila Tashfeen, Asma Sheikh   +5 more
doaj   +1 more source

Biological evaluation of the effect of sugammadex on hemostasis and bleeding [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundNotification of sugammadex has been supplemented with a section on hemostasis, including a longer clotting time in the first minutes following injection, without any documented clinical consequences.
Julien Raft, Philippe Guerci, Valentin Harter, Thomas Fuchs-Buder, Claude Meistelman   +4 more
doaj   +1 more source

Hemostatic activities of methanol leaf extracts of Croton megalocarpus Hutch and Lantana camara Linn

Journal of Advanced Biotechnology and Experimental Therapeutics, 2021
Hemostasis is the natural mechanism by which blood is kept in a fluid state in circulation with the ability to cause clotting at an injury site. The effects of Croton megalocarpus Hutch and Lantana camara Linn plants leaves on blood coagulation has not ...
Hezron Mutisya Muindi, Cromwell Mwiti Kibiti, Mathew Piero Ngugi   +2 more
doaj   +1 more source

Performance Evaluation of Four Activated Partial Thromboplastin Time Reagents

Pharmacology and Clinical Pharmacy Research, 2018
Activated Partial Thromboplastin Time (APTT) is a hematological examination to identify hemostatic abnormalities. This study aimed to compare the performance evaluation of four APTT reagents, i.e., CK Prest, Pathromtin SL, Actin SL, and Cephascreen.
Peppi Z. Yuzaqi, Eli Halimah, Tatat Noviani   +2 more
doaj   +1 more source

Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT

Advances in Hematology, 2014
The pharmacological effects of amphetamine, procaine, procainamide, DOPA, isoproterenol, and atenolol upon activated partial thromboplastin time in the absence and presence of acetaldehyde have been investigated.
La'Teese Hall, Sarah J. Murrey, Arthur S. Brecher   +2 more
doaj   +1 more source

Association of coagulation profile with microvascular complications and glycemic control in type 2 diabetes mellitus – a study at a tertiary care center in Delhi

Hematology, Transfusion and Cell Therapy, 2019
Introduction: Type 2 diabetes mellitus, characterized by insulin resistance, corresponds to approximately 90% of cases of diabetes worldwide. Hyperglycemia in diabetes contributes to hyperfibrinogenemia and activates the coagulation cascade thereby ...
Charu Agarwal, Kashish Bansal, Mukta Pujani, Kanika Singh, Varsha Chauhan, Deepshikha Rana, Shveta Lukhmana   +6 more
doaj   +1 more source

Prothrombine and activated partial thromboplastin time are prolonged in hepatic cirrhosis

Universa Medicina, 2016
Background Chronic hepatitis and hepatic cirrhosis are chronic liver diseases that cause disorders of liver function, such as the formation of platelets and coagulation factors (prothrombin time/PT and activated partial thromboplastin time/APTT ...
Edward Kurnia Setiawan Limijadi, Lisyani Budi Suromo, Imam Budiwiyono   +2 more
doaj   +1 more source

The role of hemostatic changes in the pathogenesis of diabetic retinopathy

Journal of Education, Health and Sport, 2022
Introduction: The paper presents the results of the hemostasis system of rats with experimental diabetic retinopathy. Material and methods: Experimental studies were performed on white Wistar rats, which were divided into 2 groups: 1st group – intact
Nataliya Preys, Ivan Savytskyi
doaj   +1 more source

An Evaluation of the Activated Partial Thromboplastin Time Waveform [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2017
The activated partial thromboplastin time (APTT) waveform includes several parameters that are related to various underlying diseases. The APTT waveform was examined in various diseases. Regarding the pattern of APTT waveform, a biphasic pattern of the first or second derivative curve (DC) was observed in patients with hemophilia and patients positive ...
Takeshi, Matsumoto, Hideo, Wada, Naoki, Fujimoto, Junki, Toyoda, Yasunori, Abe, Kohshi, Ohishi, Yoshiki, Yamashita, Makoto, Ikejiri, Kei, Hasegawa, Kei, Suzuki, Hiroshi, Imai, Kaname, Nakatani, Naoyuki, Katayama   +12 more
openaire   +2 more sources