Results 31 to 40 of about 84,070 (269)

Risk for excessive anticoagulation during hemodialysis is associated with type of vascular access and bedside coagulation testing: Results of a cross-sectional study

Frontiers in Medicine, 2022
BackgroundRecommendations and practice patterns for heparin dosing during hemodialysis show substantial heterogeneity and are scantly supported by evidence.
Marijke De Troyer, Karl Martin Wissing, Dieter De Clerck, Marie-Laure Cambier, Tom Robberechts, Annelies Tonnelier, Karlien François   +6 more
doaj   +1 more source

Influence of factor XII deficiency on activated partial thromboplastin time (aPTT) in critically ill patients

Journal of Thrombosis and Thrombolysis, 2019
FXII deficiency results in spontaneous prolongation of activated partial thromboplastin time (aPTT), which is widely used to monitor thromboprophylaxis. Misinterpretation of spontaneously prolonged aPTT may result in omission of thromboembolic treatment ...
M. Bachler, C. Niederwanger, T. Hell, J. Höfer, Dominic Gerstmeyr, B. Schenk, B. Treml, D. Fries   +7 more
semanticscholar   +1 more source

Evaluation of Antifactor-Xa Heparin Assay and Activated Partial Thromboplastin Time Values in Patients on Therapeutic Continuous Infusion Unfractionated Heparin Therapy

Clinical and applied thrombosis/hemostasis, 2019
Clinical uncertainty exists regarding which assay should be designated as the standard monitoring coagulation test for intravenous unfractionated heparin (UFH).
K. McLaughlin, J. Rimsans, K. Sylvester, J. Fanikos, D. Dorfman, P. Senna, J. Connors, S. Goldhaber   +7 more
semanticscholar   +1 more source

The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time [PDF]

Cureus, 2021
Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subject. Nine studies were included.
Samara, Evangelia, Stamatiou, Konstantinos, Balanika, Marina, Tzimas, Petros   +3 more
openaire   +2 more sources

Mixing Studies in Patients With Prolonged Activated Partial Thromboplastin Time or Prothrombin Time.

Anesthesia and Analgesia, 2019
BACKGROUND Patients presenting for surgery may have isolated or combined prolonged activated partial thromboplastin time (aPTT) and/or prothrombin time (PT).
H. Benzon, M. Park, R. McCarthy, M. Kendall, P. Lindholm   +4 more
semanticscholar   +1 more source

Performance of Anti-Factor Xa Versus Activated Partial Thromboplastin Time for Heparin Monitoring Using Multiple Nomograms

Clinical and applied thrombosis/hemostasis, 2017
The purpose of this study was to compare the performance of anti-factor Xa concentration versus activated partial thromboplastin time (aPTT) monitoring with multiple indication-specific heparin nomograms.
Emily M Whitman-Purves, James C. Coons, T. Miller, Jeannine V Dinella, A. Althouse, M. Schmidhofer, Roy E. Smith   +6 more
semanticscholar   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +2 more sources

Implications of deranged activated partial thromboplastin time for anaesthesia and surgery

Anaesthesia, 2018
Bleeding during and after surgery ranges from trivial to fatal. Bleeding is in part determined by the patient's coagulation status. The UK National Institute for Health and Care Excellence recommends a pre‐operative clotting test for patients with a ...
E. Loizou, D. Mayhew, V. Martlew, B. Murthy   +3 more
semanticscholar   +1 more source

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, EarlyView.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +2 more sources

An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform

Clinical and applied thrombosis/hemostasis, 2018
The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA).
Haruna Katayama, Takeshi Matsumoto, H. Wada, N. Fujimoto, Junki Toyoda, Y. Abe, K. Ohishi, Y. Yamashita, M. Ikejiri, K. Habe, N. Katayama   +10 more
semanticscholar   +1 more source