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Shortened activated partial thromboplastin time: causes and management
Blood Coagulation & Fibrinolysis, 2010Throughout the long history of the hemostasis laboratory, and as an evaluation of the coagulation cascade, the results of the activated partial thromboplastin time (APTT) have primarily been considered as an index of loss-of-function and rarely as an index of gain-of-function.
LIPPI, Giuseppe +4 more
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Comparison of Several Activated Partial Thromboplastin Time Methods
American Journal of Clinical Pathology, 1975Activated partial thromboplastin times (APTT's) performed with a semi-automated electrical-conductivity type of clot timer on plasmas from patients with hepatic disease and intravascular coagulation, and on warfarin or heparin therapy, were significantly lower than when done on the same plasmas with either a manual optical method or an automated ...
R J, Morin, D, Willoughby
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Comparison of Activated Partial Thromboplastin Time Reagents
Laboratory Medicine, 1988This study compared two activated partial thromboplastin time (aPTT) reagents with respect to their sensitivity for detection of factor deficiencies in the intrinsic pathway of coagulation and to heparin concentration. Significant differences were found with respect to the ability of the reagents to detect intrinsic factor deficiencies.
Joseph T. Pedersen +2 more
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Use of the Activated Partial Thromboplastin Time
Annals of Internal Medicine, 1988Excerpt To the Editor:In connection with a recent article (1), I pose a question. Should peridural anesthesia in women with otherwise normal bleeding history be preceded by coagulation tests to pre...
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Effect of Warfarin on the Activated Partial Thromboplastin Time
Drug Intelligence & Clinical Pharmacy, 1986Outpatients followed in an anticoagulation clinic were studied retrospectively to determine the effect of warfarin on the activated partial thromboplastin time (APTT). Twenty-nine patients were studied in part 1 of the trial to determine whether their APTT values were elevated when their prothrombin time (PT) was within 1.5 to 2.5 times the control PT.
V M, Hauser, S L, Rozek
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Bleeding in Patients With Activated Partial Thromboplastin Time Inhibitors
Southern Medical Journal, 1982We present a case in which an activated partial thromboplastin time (aPTT) inhibitor may have significantly contributed to prolonged bleeding in a patient and review five similar cases. The possibility of an aPTT inhibitor should be considered in the evaluation of patients with unexplained prolongation of PTT and PT.
S B, Kalish +3 more
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The activated partial thromboplastin time (APTT)
1992The term partial thromboplastin is used to distinguish the reagent from that used in the prothrombin time, since the APTT reagent lacks the apoprotein component of the complete tissue thromboplastin. The APTT is the main test for screening for intrinsic clotting defects including haemophilia. It is also used for detection of lupus anticoagulant and for
L. Poller, J. M. Thomson
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Kaolin-correctable Prolongation of the Activated Partial Thromboplastin Time
American Journal of Clinical Pathology, 1980Seven patients who had normal prothrombin times but prolonged activated partial thromboplastin times (aPTT) are described. The prolonged aPTT, obtained with micronized silica as the contact activating agent in a semi-automated optical end-point system, a nonautomated optical end-point system, and a conductivity end-point system, corrected to normal ...
M F, Briselli, L, Ellman
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Activated partial thromboplastin time measurements in citrated canine plasma
Journal of Comparative Pathology, 1992Activated partial thromboplastin times (APTT) were determined for citrated plasma samples obtained from healthy Beagle dogs. Significant variations were observed with different reagents and analysers in these studies emphasizing the importance of analytical variables in APTT measurements.
G O, Evans, R M, Flynn
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Micro-Activated Partial Thromboplastin Time in Diluted Capillary Blood
Pathophysiology of Haemostasis and Thrombosis, 1984A sensitive micromethod for estimating the activated partial thromboplastin time in diluted capillary blood with excellent reproducibility is presented, as are results of test conditions with regard to sampling, calcium concentration, osmolarity of the diluent and the influence of the packed cell volume.
A C, Zondag, G E, van Zanen
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