Results 51 to 60 of about 122,624 (309)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Impact of Cloud Computing on Developing Accounting Education at Private Universities in the Republic of Yemen: A Field Study

مجلة جامعة العلوم والتكنولوجيا للعلوم الإدارية والإنسانية, 2023
The study aimed to identify and measure the impact of cloud computing on developing accounting education from the perspective of academics in the accounting department and experts and technicians in the field of information technology in the Republic of
Sultan Ali Ahmed Al-Sorihi, Eslah Abdulwali Alshameri   +1 more
doaj   +1 more source

EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS [PDF]

, 2017
The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment,
Larsson, Connie A
core   +1 more source

The Education Quality Measuring: American Experience [PDF]

, 2018
The US Higher Education Reform is due to certain processes of competitiveness, market orientation, the tendency to form a single space for education. The American system of Higher Education has integrated the best in the education of other countries and ...
Marushkevych, A. (Alla), Zvarych, I. (Iryna)   +1 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Identification of levels of sustainable consciousness of teachers in training through an e-portfolio [PDF]

, 2018
The contents of Education for Sustainable Development should be included in teachers’ initial and advanced training programs. A sustainable consciousness is one of the main foundations for determining the key competences for sustainability.
Colás Bravo, María Pilar, Conde Jiménez, Jesús, Magnoler, Patrizia   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Would Teachers’ Professional Collaboration Promote Cognitively Activating Teaching Practices? The Moderating Role of Collective Innovativeness

ECNU Review of Education
Purpose This study examines the relationship between teachers’ professional collaboration and their use of cognitively activating teaching practices.
Mehmet Şükrü Bellibaş, Dong Nguyen, Sedat Gümüş   +2 more
doaj   +1 more source

Impact of Teaching and Learning Modes on Graduates’ Social and Entrepreneurial Skills Development: A Comparative Analysis

Education Sciences
There is a growing interest in researching the impact of different modes of learning and teaching on the non-academic outcomes of graduates, such as their employment outcomes. This study examines the impact of teaching and learning modes on the perceived
Ana Tecilazić, Ivana Ogrizek Biškupić, Mislav Balković   +2 more
doaj   +1 more source

Editorial: Economic Education and Constructivist Didactics

Journal of Social Science Education, 2004
Against the background of constructivist theories, this article is on the lookout for complex teaching-learning arrangements and participant-activating methods for economic education as well as it investigates didactic models that are part of the ...
Andreas Fischer
doaj   +1 more source