Results 281 to 290 of about 693,055 (312)

Activating Transcription Factor 4 Modulates BDNF Release from Microglial Cells

Journal of Molecular Neuroscience, 2013
Pathogenic pain is a common sign of many diseases. The mechanism is unclear. Activating transcription factor 4 (ATF4) plays a critical role in cell activation. Brain-derived neurotrophic factor (BDNF) is an important molecule in pathogenic pain. This study aims to investigate the role of ATF4 in inducing BDNF release from microglial cells.
Pengling, Sun, Xiangnan, Li, Chengwen, Chen, Qianbo, Chen, Qing, Ouyang, Fangting, Liu, Zhenghua, Xiang, Hongbin, Yuan   +7 more
openaire   +2 more sources

Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation

AIDS Research and Human Retroviruses, 2012
Activating transcription factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, and redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
Elisabetta, Caselli, Sabrina, Benedetti, Valentina, Gentili, Jessica, Grigolato, Dario, Di Luca   +4 more
openaire   +2 more sources

In vitro activation of heat shock transcription factor by 4-hydroxynonenal

Chemico-Biological Interactions, 1992
In the activation of eukaryotic heat shock genes, the acquisition of a binding ability to specific DNA sequence by a transcriptional activator, heat shock factor (HSF), is believed to be a crucial step. The induction of this new DNA binding activity of HSF is also obtained in a cell-free system (in vitro activation) by hyperthermia or at physiological ...
F, Cajone, M, Crescente
openaire   +2 more sources

Regulation of FGF-4 Enhancer Activity by Transcription Factor NF-Y

Biochemical and Biophysical Research Communications, 1995
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has ...
M, Bryans, J M, Lucas, T J, Knobloch, N M, Wilkie, J C, Lang   +4 more
openaire   +2 more sources

SUMOylation can regulate the activity of ETS-like transcription factor 4

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
ETS-like transcription factor 4 (ELK4) (a.k.a. serum response factor accessory protein 1) belongs to the ternary complex factor (TCF) subfamily of E twenty-six (ETS) domain transcription factors. Compared to the other TCF subfamily members, ELK1 and ELK3 (NET), there is limited information of the mechanisms regulating the ELK4 activity.
Sanna, Kaikkonen, Harri, Makkonen, Miia, Rytinki, Jorma J, Palvimo   +3 more
openaire   +2 more sources

Activation transcription factor-4 and the acute vascular response to injury

Journal of Molecular Medicine, 2010
Atherosclerosis is a complex fibroproliferative-inflammatory process triggered by vascular injury. Transcription factors play an important role in the control of genes that effect critical changes in the vessel wall. Recent evidence indicates an emerging role for activation transcription factor 4 (ATF4), a master regulator for evolutionarily conserved ...
Kristine P, Malabanan, Levon M, Khachigian   +1 more
openaire   +2 more sources

Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary

Molecular and Cellular Endocrinology, 1999
The two-hybrid system that identifies protein-protein interactions in a yeast expression system was used to investigate porcine anterior pituitary transcription factors. Four cDNA clones of a protein interacting with the leucine zipper domain of porcine cJun were obtained.
Y, Kato, Y, Koike, K, Tomizawa, S, Ogawa, K, Hosaka, S, Tanaka, T, Kato   +6 more
openaire   +2 more sources

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

Biochemical Journal, 2012
Nutrient deprivation or starvation frequently correlates with amino acid limitation. Amino acid starvation initiates a signal transduction cascade starting with the activation of the kinase GCN2 (general control non-derepressible 2) phosphorylation of eIF2 (eukaryotic initiation factor 2), global protein synthesis reduction and increased ATF4 ...
Ana Luísa, De Sousa-Coelho, Pedro F, Marrero, Diego, Haro   +2 more
openaire   +2 more sources

Sorafenib induces renal cell carcinoma apoptosis via upregulating activating transcription factor 4.

Die Pharmazie, 2018
Previous studies have shown sorafenib to function as a multitargeted tyrosine kinase inhibitor in different tumors. However, whether sorafenib improves renal cell carcinoma (RCC) through activating transcription factor 4 (ATF4) has never been explored. In the current study, we showed that sorafenib could suppress RCC cell viability in a time- and dose ...
Qifei Wang, Qifei Wang, Guangzhen Wu, Guangzhen Wu, Xiangyu Che, Xiangyu Che, Quanlin Li, Quanlin Li, Zhiwei Zhang, Zhiwei Zhang, Qizhen Tan, Qizhen Tan   +5 more
openaire   +2 more sources

Activating Transcription Factor 4 (ATF4) promotes HIV-1 activation

2012
Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GENTILI, Valentina, GRIGOLATO, Jessica, DI LUCA, Dario   +4 more
openaire   +1 more source