Results 261 to 270 of about 17,248,721 (282)
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Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
Biochemical Journal, 2012Nutrient deprivation or starvation frequently correlates with amino acid limitation. Amino acid starvation initiates a signal transduction cascade starting with the activation of the kinase GCN2 (general control non-derepressible 2) phosphorylation of eIF2 (eukaryotic initiation factor 2), global protein synthesis reduction and increased ATF4 ...
Ana Luísa, De Sousa-Coelho +2 more
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The FASEB Journal
ABSTRACT Osteoclast functioning determines homeostasis of bone texture, healing speed after bone injury, and integrity after bone remodeling. Osteoclastogenesis is tightly controlled by transcriptional factors and cytokine‐mediated signaling.
Shasha Tu +8 more
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ABSTRACT Osteoclast functioning determines homeostasis of bone texture, healing speed after bone injury, and integrity after bone remodeling. Osteoclastogenesis is tightly controlled by transcriptional factors and cytokine‐mediated signaling.
Shasha Tu +8 more
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Gene, 2016
Intermedin or adrenomedullin 2 is a set of calcitonin-related peptides with a putative tumor angiogenesis promoting activity that are formed by proteolytic processing of the ADM2 gene product. It has been proposed that the ADM2 gene is regulated by the estrogen response element (ERE) and hypoxia response elements (HRE) found within its promoter region.
Irina E. Kovaleva +3 more
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Intermedin or adrenomedullin 2 is a set of calcitonin-related peptides with a putative tumor angiogenesis promoting activity that are formed by proteolytic processing of the ADM2 gene product. It has been proposed that the ADM2 gene is regulated by the estrogen response element (ERE) and hypoxia response elements (HRE) found within its promoter region.
Irina E. Kovaleva +3 more
openaire +2 more sources
Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
Die Prolyl-4-Hydroxylase-Domäne-Enzyme 1-3 (PHD1-3) sind maßgeblich an der Regulation der Proteinstabilität der alpha-Untereinheit des Hypoxie-induzierbaren Faktors (HIF) beteiligt, welcher als wichtigster Transkriptionsfaktor der Sauerstoff-abhängigen Genexpression angesehen wird. Des Weiteren sind die PHDs auch an der Regulation Sauerstoff-abhängiger,Wottawa, Marieke Claudia +3 more
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