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Activating transcription factor 3 in immune response and metabolic regulation

Liver Research, 2017
Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic adenosine monophosphate(cAMP)-response element binding protein (CREB) family of transcription factors.
Yanqiao Zhang, Kavita Jadhav
exaly   +2 more sources

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In vitro activation of heat shock transcription factor by 4-hydroxynonenal

Chemico-Biological Interactions, 1992
In the activation of eukaryotic heat shock genes, the acquisition of a binding ability to specific DNA sequence by a transcriptional activator, heat shock factor (HSF), is believed to be a crucial step. The induction of this new DNA binding activity of HSF is also obtained in a cell-free system (in vitro activation) by hyperthermia or at physiological ...
F, Cajone, M, Crescente
openaire   +2 more sources

Activation transcription factor-4 and the acute vascular response to injury

Journal of Molecular Medicine, 2010
Atherosclerosis is a complex fibroproliferative-inflammatory process triggered by vascular injury. Transcription factors play an important role in the control of genes that effect critical changes in the vessel wall. Recent evidence indicates an emerging role for activation transcription factor 4 (ATF4), a master regulator for evolutionarily conserved ...
Kristine P, Malabanan, Levon M, Khachigian   +1 more
openaire   +2 more sources

Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary

Molecular and Cellular Endocrinology, 1999
The two-hybrid system that identifies protein-protein interactions in a yeast expression system was used to investigate porcine anterior pituitary transcription factors. Four cDNA clones of a protein interacting with the leucine zipper domain of porcine cJun were obtained.
Y, Kato, Y, Koike, K, Tomizawa, S, Ogawa, K, Hosaka, S, Tanaka, T, Kato   +6 more
openaire   +2 more sources

Regulation of FGF-4 Enhancer Activity by Transcription Factor NF-Y

Biochemical and Biophysical Research Communications, 1995
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has ...
M, Bryans, J M, Lucas, T J, Knobloch, N M, Wilkie, J C, Lang   +4 more
openaire   +2 more sources

SUMOylation can regulate the activity of ETS-like transcription factor 4

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
ETS-like transcription factor 4 (ELK4) (a.k.a. serum response factor accessory protein 1) belongs to the ternary complex factor (TCF) subfamily of E twenty-six (ETS) domain transcription factors. Compared to the other TCF subfamily members, ELK1 and ELK3 (NET), there is limited information of the mechanisms regulating the ELK4 activity.
Sanna, Kaikkonen, Harri, Makkonen, Miia, Rytinki, Jorma J, Palvimo   +3 more
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Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

IUBMB Life, 2012
AbstractIt has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy ...
Chunxia, Wang, Feifan, Guo
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Activating Transcription Factor 4 Modulates BDNF Release from Microglial Cells

Journal of Molecular Neuroscience, 2013
Pathogenic pain is a common sign of many diseases. The mechanism is unclear. Activating transcription factor 4 (ATF4) plays a critical role in cell activation. Brain-derived neurotrophic factor (BDNF) is an important molecule in pathogenic pain. This study aims to investigate the role of ATF4 in inducing BDNF release from microglial cells.
Pengling, Sun, Xiangnan, Li, Chengwen, Chen, Qianbo, Chen, Qing, Ouyang, Fangting, Liu, Zhenghua, Xiang, Hongbin, Yuan   +7 more
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Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation

AIDS Research and Human Retroviruses, 2012
Activating transcription factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, and redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
Elisabetta, Caselli, Sabrina, Benedetti, Valentina, Gentili, Jessica, Grigolato, Dario, Di Luca   +4 more
openaire   +2 more sources

Activating Transcription Factor 4 (ATF4) promotes HIV-1 activation

2012
Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GENTILI, Valentina, GRIGOLATO, Jessica, DI LUCA, Dario   +4 more
openaire   +1 more source