Results 81 to 90 of about 693,055 (312)

ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis

Frontiers in Immunology
BackgroundRenal tubulointerstitial fibrosis is a reliable predictor of progressive chronic kidney disease (CKD). Activating transcription factor 4 (ATF4) has recently emerged as a pivotal player in multiple pathophysiologic processes, particularly the ...
Songtao Feng, Songtao Feng, Yueming Gao, Zheng Wang, Weijie Ni, Yan Zhou, Mingyue Yuan, Jinyang Ge, Lu Sun, Bicheng Liu, Hui Qian, Zuolin Li   +11 more
doaj   +1 more source

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. [PDF]

, 2019
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood.
Amaravadi, Ravi K, Chinga, Frank, Conn, Crystal S, Diehl, J Alan, Fu, Weixuan, Fuchs, Serge Y, Ignatova, Zoya, Kossenkov, Andrew, Koumenis, Constantinos, Leli, Nektaria Maria, Monroy, Alexandra M, Ojha, Rani, Polte, Christine, Ruggero, Davide, Salas Salinas, Carlo, Tameire, Feven, Verginadis, Ioannis I, Wang, Paul, Ye, Jiangbin   +18 more
core  

The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4 [PDF]

Journal of Biological Chemistry, 2000
G protein-coupled receptors regulate gene expression by cellular signaling cascades that target transcription factors and their recognition by specific DNA sequences. In the central nervous system, heteromeric metabotropic gamma-aminobutyric acid type B (GABA(B)) receptors through adenylyl cyclase regulate cAMP levels, which may control transcription ...
Nehring, R., Horikawa, H., El Far, O., Kneussel, M., Brandstaetter, J., Stamm, S., Wischmeyer, E., Betz, H., Karschin, A.   +8 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells

Frontiers in Oncology, 2022
Regions of hypoxia are common in solid tumors and drive changes in gene expression that increase risk of cancer metastasis. Tumor cells must respond to the stress of hypoxia by activating genes to modify cell metabolism and antioxidant response to ...
Violet A. Kiesel, Madeline P. Sheeley, Emily M. Hicks, Chaylen Andolino, Shawn S. Donkin, Michael K. Wendt, Michael K. Wendt, Stephen D. Hursting, Stephen D. Hursting, Stephen D. Hursting, Dorothy Teegarden, Dorothy Teegarden   +11 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

eLife, 2021
Piwi-interacting RNAs (piRNAs) play essential roles in silencing repetitive elements to promote fertility in metazoans. Studies in worms, flies, and mammals reveal that piRNAs are expressed in a sex-specific manner.
Charlotte P Choi, Rebecca J Tay, Margaret R Starostik, Suhua Feng, James J Moresco, Brooke E Montgomery, Emily Xu, Maya A Hammonds, Michael C Schatz, Taiowa A Montgomery, John R Yates III, Steven E Jacobsen, John K Kim   +12 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]

, 2019
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E, Garelis, Nick E, Gowen, Benjamin G, Katibah, George E, Luteijn, Rutger D, McWhirter, Sarah M, Onia, Liberty, Raulet, David H, Woodward, Joshua J, Wyman, Stacia K, Zaver, Shivam A   +10 more
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