Results 91 to 100 of about 495,141 (240)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Branched-chain amino acid metabolism disorder promotes the progression of diabetic kidney disease by inducing podocyte apoptosis in glomeruli via activating the mTOR-ATF4-Chop/Trib3 signaling pathway

陆军军医大学学报
Objective To investigate the molecular mechanisms by which branched-chain amino acids (BCAAs) catabolic disorder induces glomerular podocyte injury, and to elucidate its role and mechanism in promoting the pathogenesis of diabetic nephropathy (DN) in a ...
TIAN Wenqi, ZHAO Xiaojuan
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Research advances on the role of the endoplasmic reticulum unfolded protein response in bone metabolism

Kouqiang hemian waike zazhi
The structural integrity of the skeletal system depends on the extracellular matrix protein network, whose synthesis and quality control are precisely regulated by the endoplasmic reticulum (ER) through the unfolded protein response (UPR).
ZHANG Qian, TANG Yi, XIA Yuxing, KANG Feiwu   +3 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice. [PDF]

Proc Natl Acad Sci U S A, 2023
Yuan F, Zhou Z, Wu S, Jiao F, Chen L, Fang L, Yin H, Hu X, Jiang X, Liu K, Xiao F, Jiang H, Chen S, Liu Z, Shu Y, Guo F.   +15 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease

BMC Biology
Background Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by specific changes in the redox balance that lead to lethal lipid peroxidation.
Antonio Currais, Kayla Sanchez, David Soriano-Castell, Nawab John Dar, K. Garrett Evensen, Salvador Soriano, Pamela Maher   +6 more
doaj   +1 more source

Erratum: Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4: Erratum. [PDF]

Theranostics, 2023
Ou L, Lan Y, Feng Z, Feng L, Yang J, Liu Y, Bian L, Tan J, Lai R, Guo R.   +9 more
europepmc   +1 more source

Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting MYC activity

Molecular Oncology
Super‐enhancer‐associated transcription factor networks define cell identity in neuroblastoma (NB). Dysregulation of these transcription factors contributes to the initiation and maintenance of NB by enforcing early developmental identity states. We report that the class I basic helix–loop–helix (bHLH) transcription factor 4 (
Nour A. Aljouda, Dewan Shrestha, Chelsea DeVaux, Rachelle R. Olsen, Satyanarayana Alleboina, Megan Walker, Yong Cheng, Kevin W. Freeman   +7 more
openaire   +3 more sources