Results 281 to 290 of about 638,455 (326)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications. [PDF]

Front Mol Biosci
Huang J, Qin J, Zhu Y, Shen A.
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Impact of excessive hypercholesterolemia in pregnancy on the placentas of the male and female offspring. [PDF]

Sci Rep
de Oliveira AA, Stokes A, Quon A, Graton ME, Spaans F, Cooke CM, Davidge ST.   +6 more
europepmc   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

Potential role of AhR in ischemia‑reperfusion injury and cancers: Focus on ferroptosis and lipid peroxidation signaling pathways (Review). [PDF]

Int J Mol Med
Liao Z, Huang M, Zhang Y, Huang S, Lei W, Shui X.   +5 more
europepmc   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

MIAT promotes tumor-infiltrating CD8⁺ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway. [PDF]

J Immunother Cancer
Zhang MX, Jing LY, Tan HT, Dai ZR, Long DZ, Liu HC, Yu AZ, Wang B, Chen ZY, Luo JH, Chen ZH, Wang JF.   +11 more
europepmc   +1 more source

Mechanistic insights into Nrf2-driven pathogenesis and therapeutic targeting in spinal cord injury. [PDF]

Front Immunol
Xie T, Xu J, Liu X, Yu Y, Lu Y, Wang T, Gao F, Yuan H.   +7 more
europepmc   +1 more source

Upregulated Krüppel-like factor 5 promotes hepatocellular carcinoma progression by activating Wnt3a signaling. [PDF]

Genes Dis
Sai W, Yang J, Qiu L, Xu M, Yao M, Yao D.   +5 more
europepmc   +1 more source