Results 261 to 270 of about 692,400 (286)
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Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2000One of the early events in inflammation and epithelial restitution of the gastrointestinal tract is the up-regulation of secretory peptides belonging to the trefoil factor family (TFF) that promote cell migration, protect and heal the mucosa. Their major expression site is stomach (TFF1, TFF2) and intestine (TFF3).
E D, Al-azzeh +3 more
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Transcriptional Activation of the Factor VIII Gene in Liver Cell Lines by Interleukin-6
Thrombosis and Haemostasis, 1998SummaryCirculating factor VIII (fVIII) levels increase during inflammation suggesting that fVIII synthesis or secretion is stimulated during acute inflammation. To examine the mechanisms underlying this increase in circulating factor VIII, we have developed a sensitive and reliable semi-quantitative assay for fVIII mRNA utilising competitive reverse ...
D, Stirling, W A, Hannant, C A, Ludlam
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Journal of Molecular Neuroscience, 2020
Spinal cord injury (SCI) is one of the most common devastating injuries, with little possibility of recovery in humans. However, zebrafish efficiently regenerate functional nervous system tissue after SCI. Therefore, the spinal cord transection model of adult zebrafish was applied to explore the role of ATF6 in neuro-recovery.
Zhe Ji +7 more
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Spinal cord injury (SCI) is one of the most common devastating injuries, with little possibility of recovery in humans. However, zebrafish efficiently regenerate functional nervous system tissue after SCI. Therefore, the spinal cord transection model of adult zebrafish was applied to explore the role of ATF6 in neuro-recovery.
Zhe Ji +7 more
openaire +2 more sources
Nature Genetics, 2006
The molecular basis of nephronophthisis, the most frequent genetic cause of renal failure in children and young adults, and its association with retinal degeneration and cerebellar vermis aplasia in Joubert syndrome are poorly understood. Using positional cloning, we here identify mutations in the gene CEP290 as causing nephronophthisis.
Sayer, John A. +41 more
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The molecular basis of nephronophthisis, the most frequent genetic cause of renal failure in children and young adults, and its association with retinal degeneration and cerebellar vermis aplasia in Joubert syndrome are poorly understood. Using positional cloning, we here identify mutations in the gene CEP290 as causing nephronophthisis.
Sayer, John A. +41 more
openaire +4 more sources
Journal of Neurochemistry
Abstract The impact of primary and secondary injuries of spinal cord injury (SCI) results in the demise of numerous neurons, and there is still no efficacious pharmacological intervention for it. Recently, studies have shown that endoplasmic reticulum stress (ERS) plays a pivotal role in recovery of neurological ...
Yong Chang +5 more
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Abstract The impact of primary and secondary injuries of spinal cord injury (SCI) results in the demise of numerous neurons, and there is still no efficacious pharmacological intervention for it. Recently, studies have shown that endoplasmic reticulum stress (ERS) plays a pivotal role in recovery of neurological ...
Yong Chang +5 more
openaire +2 more sources
Aberrant expression of Activating Transcription Factor 6 (ATF6) in major psychiatric disorders
Psychiatry Research, 2012Somayeh, Kazeminasab +5 more
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Binding of general transcription factor TFIIB to an acidic activating region
Nature, 1991Danny Reinberg, Michael R Green
exaly
Cdk-activating kinase complex is a component of human transcription factor TFIIH
Nature, 1995Ronny Drapkin, Danny Reinberg
exaly