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SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential. [PDF]
Neuromolecular MedAlameen AAM +6 more
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Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy. [PDF]
J Transl MedLiu J +6 more
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Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules. [PDF]
Front Med (Lausanne)Fu Y, Xiao L.
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International Journal of Neuroscience, 2020
Amyloid plaques are the most important pathological hallmarks of Alzheimer's disease. The deposition of amyloid plaques will cause ER Stress. Activating Transcription Factor 6(ATF6) is a sensor of ER Stress. However, the role of ATF6 in Alzheimer's disease has not been reported yet.The levels of β-site APP-cleaving enzyme 1 (BACE1) and Aβ1-42 were ...
Yayun, Du +5 more
openaire +4 more sources
Amyloid plaques are the most important pathological hallmarks of Alzheimer's disease. The deposition of amyloid plaques will cause ER Stress. Activating Transcription Factor 6(ATF6) is a sensor of ER Stress. However, the role of ATF6 in Alzheimer's disease has not been reported yet.The levels of β-site APP-cleaving enzyme 1 (BACE1) and Aβ1-42 were ...
Yayun, Du +5 more
openaire +4 more sources
Levels of activating transcription factor 6 alpha (ATF6α) in Alzheimer’s disease
Alzheimer's & Dementia, 2023AbstractBackgroundAlzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide. More than 40 million people currently suffer from AD, and such prevalence tends to increase considerably in the coming decades due to increased human longevity.
Mariana Gomes Chauvet +3 more
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MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6
Tissue and Cell, 2021The recovery of spinal cord injury (SCI) involves multiple factors, of which miRNAs take an important part. In this study, we evaluated the function of microRNA-211-5p (miR-211-5p) on SCI in a rat model. SCI model was established using modified Allen's weight-drop method and Basso-Bcattie-Bresnahan score was applied to assess the locomotor function ...
Haocong, Zhang +4 more
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Transcription Factor GATA-6 Recruits PPARα to Cooperatively Activate Glut4 Gene Expression
Journal of Molecular Biology, 2012Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that regulates energy metabolism, but its precise mechanisms remain unknown. Here, we demonstrate that the PPARα agonist fenofibrate activated expression of the glucose transporter Glut4.
Chun-Xia, Yao +9 more
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