Results 1 to 10 of about 28,246 (239)

ATF6 and pS6K as prognostic biomarkers in newly diagnosed diffuse large B-cell lymphoma [PDF]

Scientific Reports
This study aimed to investigate the clinical and prognostic significance of activating transcription factor 6 (ATF6) and phosphorylated S6 kinase (pS6K) expression in newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Shuang Su, Lili Wu, Chen Huang, Lianjing Wang, Weijing Li, Wei Liu, Lihong Liu   +6 more
doaj   +2 more sources

Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models [PDF]

Scientific Reports
Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal
Allyssa Bradley, Soyoung Park, Soyeon Park, Kyle Kim, Angela Galdamez, Hyejung Min, Monica Sophia Diaz-Aguilar, M. Elizabeth Hartnett, Eun-Jin Lee, Jonathan H. Lin   +9 more
doaj   +2 more sources

Activating transcription factor 6 promotes proliferation, migration and invasion of PC3 human prostate cancer cells through Hippo-YAP signaling pathway

陆军军医大学学报, 2023
Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan, YANG Zongke, LIU Qingyuan, ZHANG Jindong, ZHU Huixuan, WANG Delin   +5 more
doaj   +1 more source

Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage

European Journal of Medical Research, 2023
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway.
Bingzi Dong, Ying Sun, Bingfei Cheng, Yu Xue, Wei Li, Xiaofang Sun   +5 more
doaj   +1 more source

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

iScience, 2021
Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive.
Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen   +10 more
doaj   +1 more source

Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis

Cells, 2020
The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in ...
Erik A. Blackwood, Alina S. Bilal, Winston T. Stauffer, Adrian Arrieta, Christopher C. Glembotski   +4 more
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +10 more sources

Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Disease Models & Mechanisms, 2020
Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR).
Eric M. Clark, Hannah J. T. Nonarath, Jonathan R. Bostrom, Brian A. Link   +3 more
doaj   +1 more source

ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model

Scientific Reports, 2021
Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant ...
Eun-Jin Lee, Priscilla Chan, Leon Chea, Kyle Kim, Randal J. Kaufman, Jonathan H. Lin   +5 more
doaj   +1 more source

Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats

Frontiers in Surgery, 2021
Background: Normothermic machine perfusion (NMP) could be beneficial for organ retrieval from donors after cardiac death (DCD). Activating transcription factor 6 (ATF6) was recently shown to mitigate liver ischemia/reperfusion injury and confer ...
Nuo Cheng, Ji-Hua Shi, Yang Jin, Yuan-Bin Shi, Xu-Dong Liu, Hua-Peng Zhang, Sheng-Li Cao, Han Yang, Wen-Zhi Guo, Shui-Jun Zhang   +9 more
doaj   +1 more source