Results 1 to 10 of about 21,147 (240)
ATF6 modulates SREBP2-mediated lipogenesis [PDF]
EMBO Journal, 2004 Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis.
Lingfang Zeng +2 more
exaly +7 more sources
A lifetime of stress: ATF6 in development and homeostasis [PDF]
Journal of Biomedical Science, 2018 Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors.
Robert F. Hillary, Una FitzGerald
doaj +6 more sources
Mineral trioxide aggregate induces osteoblastogenesis via Atf6
Bone Reports, 2015 Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells.
Toyonobu Maeda +5 more
doaj +4 more sources
Molecular mechanism of ATF6 in unfolded protein response and its role in disease
HeliyonActivating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing ...
Yingying Lei +5 more
exaly +4 more sources
ATF6 as a Nodal Regulator of Proteostasis in the Heart [PDF]
Frontiers in Physiology, 2020 Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include protein synthesis, folding, trafficking,
Christopher C. Glembotski +3 more
doaj +3 more sources
Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement
PharmaceuticalsBackground/Objectives: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance ...
Saikat Fakir, Nektarios Barabutis
doaj +4 more sources
Proteostasis and Beyond: ATF6 in Ischemic Disease [PDF]
Trends in Molecular Medicine, 2019 Endoplasmic reticulum (ER) stress is a pathological hallmark of numerous ischemic diseases, including stroke and myocardial infarction (MI). In these diseases, ER stress leads to activation of the unfolded protein response (UPR) and subsequent adaptation of cellular physiology in ways that dictate cellular fate following ischemia.
Christopher C Glembotski +2 more
exaly +3 more sources
Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway. [PDF]
PLoS PathogensCoronaviruses (CoVs) encode a variety of transmembrane proteins that are translated and processed at the endoplasmic reticulum (ER). Three host ER resident transmembrane proteins, activating transcription factor 6 (ATF6), inositol-requiring enzyme 1 ...
Taylor M Caddell +4 more
doaj +2 more sources
ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer
Molecular Oncology, 2018 Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to ...
Chun-Yu Liu +2 more
exaly +2 more sources
陆军军医大学学报, 2023 Objective To investigate the effects of activating transcription factor 6 (ATF6) on the proliferation, migration and invasion of prostate cancer PC3 cells.
LIU Hengchuan +5 more
doaj +1 more source