Results 31 to 40 of about 21,147 (240)

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. [PDF]

PLoS Genetics, 2014
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR).
Deanna L Howarth, Claudia Lindtner, Ana M Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C Sadler   +7 more
doaj   +1 more source

Stress-independent induction of XBP1s, ATF6, or XBP1s and ATF6 creates 4 distinct endoplasmic reticulum proteostasis environments in SupT1^DAX cells (basal, +XBP1s, +ATF6, and +XBP1s/+ATF6).

, 2022
(A) Chemical genetic strategy to orthogonally regulate XBP1s and ATF6 in SupT1DAX cells. (B–D) RNA sequencing (RNA-Seq) analysis of the transcriptomic consequences of (B) XBP1s, (C) ATF6, and (D) XBP1s/ATF6 induction. Transcripts that were differentially
Yu Meng Zhang (12107344), Tiffani Hui (12107338), Yu-Shan Lin (519689), Anna I. Ponomarenko (5753729), Matthew D. Shoulders (1323849), Jessica E. Patrick (12107335), Samuel J. Hendel (6083825), Emmanuel E. Nekongo (1433023), C. Brandon Ogbunugafor (7207766), Angela M. Phillips (5753726), Rebecca M. Sebastian (12107341), Jimin Yoon (9646685), Vincent L. Butty (8957051)   +12 more
core   +1 more source

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

Frontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou, Simin Zhou, Simin Zhou, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Pei Huang, Pei Huang, Pei Huang, Bin Xiang, Bin Xiang, Bin Xiang, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Huaping Dong, Huaping Dong, Huaping Dong, Gang Zhang, Gang Zhang, Gang Zhang, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +26 more
doaj   +1 more source

Regulating the trafficking of the unfolded protein response (UPR) reporter ATF6 [PDF]

, 2023
The activating transcription factor 6 (ATF6) is one of the three membrane proteins, which responds to misfolded protein induced stress, in the endoplasmic reticulum (ER).
Tungkum, Wanida
core   +1 more source

Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]

Medicinski Podmladak
Endoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka, Stanojević Željka   +1 more
doaj   +1 more source

Transcriptional Factor ATF6 is Involved in Odontoblastic Differentiation [PDF]

Journal of Dental Research, 2014
ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in gene expression were evaluated over time, and localization of ATF6 was determined by ...
J W, Kim, H, Choi, B C, Jeong, S H, Oh, S W, Hur, B N, Lee, S H, Kim, J E, Nör, J T, Koh, Y C, Hwang   +9 more
openaire   +2 more sources

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

Journal of Biological Chemistry, 2000
ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6 has been implicated in the endoplasmic reticulum (ER) stress response pathway since it can activate expression of GRP78 and other genes induced by the ER stress response.
Y, Wang, J, Shen, N, Arenzana, W, Tirasophon, R J, Kaufman, R, Prywes   +5 more
openaire   +2 more sources

Mutation of ATF6 causes autosomal recessive achromatopsia [PDF]

Human Genetics, 2015
Achromatopsia (ACHM) is an early-onset retinal dystrophy characterized by photophobia, nystagmus, color blindness and severely reduced visual acuity. Currently mutations in five genes CNGA3, CNGB3, GNAT2, PDE6C and PDE6H have been implicated in ACHM. We performed homozygosity mapping and linkage analysis in a consanguineous Pakistani ACHM family and ...
Muhammad Ansar, Suzanne M. Leal, Huma Qureshi, Fareeha Zulfiqar, Kwanghyuk Lee, Naeem Mahmood Ashraf, Ehsan Ullah, Xin Wang, Sundus Sajid, Falak Sher Khan, Muhammad Aminuddin, Joshua D. Smith, Jay Shendure, Michael J. Bamshad, Deborah A. Nickerson, Abdul Hameed, Saima Riazuddin, Zubair M. Ahmed, Wasim Ahmad, Suzanne M. Leal   +19 more
openaire   +2 more sources

Roles and Clinical Significances of ATF6, EMC6, and APAF1 in Prognosis of Pancreatic Cancer

Frontiers in Genetics, 2022
Background: Pancreatic cancer (PC) is prevalent among malignant tumors with poor prognosis and lacks efficient therapeutic strategies. Endoplasmic reticulum (ER) stress and apoptosis are associated with chronic inflammation and cancer progression ...
Wang Xiao, Rong-Chang Cao, Wan-Jun Yang, Jie-Hui Tan, Ruo-Qi Liu, He-Ping Kan, Lei Zhou, Na Zhang, Zhi-Ye Chen, Xue-Mei Chen, Jia Xu, Guo-Wei Zhang, Peng Shen   +12 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions. [PDF]

J Pathol
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Song L, Liu Y, Xu C, Zhang Y, Xu K, Yao D, Huang X.   +6 more
europepmc   +2 more sources