Results 51 to 60 of about 21,147 (240)

ATF6 localization in differentiated Caco-2.

, 2012
(A) Difference between nuclear and cytoplasmic expression of ATF6. Positive slope indicates translocation of ATF6 into the nucleus. (B) Dual channel overlay of Hoechst (blue) and ATF6 (red) fluorescence in untreated Caco-2 cells.
Liz Kuriakose (144764), Mina Suh (144758), Laurie C. Haws (144766), Yuriy Fedorov (144753), Daniel D. Brown (144755), Deborah M. Proctor (144761), Chad M. Thompson (144752), Mark A. Harris (144770)   +7 more
core   +1 more source

Toll-like receptor 4-mediated endoplasmic reticulum stress induces intestinal paneth cell damage in mice following CLP-induced sepsis

Scientific Reports, 2022
A marked elevation of TLR4 was observed in various organs of septic mice. The mechanism of TLR4 in intestinal epithelial cell damage in sepsis remains unclear.
Yijie Wang, Dapeng Zhang, Congxin Li, Xue Wu, Chen He, Xiaolin Zhu, Haiyan Zhao, Lingjie Mu   +7 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

The non-canonical mechanism of ER stress-mediated progression of prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing.
Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli, Thomas S. Payne, Robert Powers, Alexander Y. Lushnikov, Amanda J. Macke, Armen Petrosyan   +20 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Polysulfides promote ATF6 oligomerization via persulfidation to modulate ER stress responses

Redox Biochemistry and Chemistry
ATF6 is a UPR sensor regulated by redox modification of luminal cysteine residues. Although polysulfides modulate proteins through cysteine persulfidation, their effect on ATF6 has been unclear.
Shin Koike, Norihiro Shibuya, Yuki Ogasawara   +2 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.

, 2021
Impaired function of the endoplasmic reticulum (ER stress) is a hallmark of many human diseases including stroke. To restore ER function in stressed cells, the unfolded protein response (UPR) is induced, which activates 3 ER stress sensor proteins ...
Liu, Shuai, Zhao, Shengli, Yu, Zhui, Glembotski, Christopher C, Sheng, Huaxin, Paschen, Wulf, Warner, David S, Yang, Wei   +7 more
core   +1 more source

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Cellular Physiology and Biochemistry, 2018
Background/Aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis.
Rui Zhou, Long Yi, Xikun Ye, Xianglong Zeng, Kai Liu, Yu Qin, Qianyong Zhang, Mantian Mi   +7 more
doaj   +1 more source

Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER [PDF]

Cell Cycle, 2008
The highly organized structure of the Golgi apparatus becomes compromised during mitosis. The Golgi cisternae unstack and form vesicles, which are then partitioned into the daughter cells. Here, we analyzed the fate of the SREBP and ATF6, two key transcription factors of sterol biogenesis and the unfolded protein response, respectively.
René, Bartz, Joachim, Seemann
openaire   +2 more sources