Results 51 to 60 of about 28,246 (239)

Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That Is Shared with the Viral Transcription Factor, VP16 [PDF]

Journal of Biological Chemistry, 2002
ATF6 is a 670-amino acid endoplasmic reticulum (ER) transmembrane protein that is cleaved in response to ER stress. The resulting N-terminal fragment of approximately 400 amino acids translocates to the nucleus and activates selected ER stress-inducible genes, such as GRP-78 and sarco/endoplasmic reticulum ATPase, which are required for cell survival ...
Donna J, Thuerauf, Lisa E, Morrison, Holly, Hoover, Christopher C, Glembotski   +3 more
openaire   +2 more sources

Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier

Cancer Biology & Medicine
Objective: Migrasomes, an emerging class of migration-facilitating membranous extracellular vesicles, remain largely uncharted in the intricate landscape of tumor metastasis.
Song Wang, Guohao Gu, Xinmiao Xian, Jun Li, Di Zhang, Jianran Guo, Anqi Zhang, Shen Chen, Dong Yan, Bingwu Yang, Meng An, Wei Zhang, Bo Fu   +12 more
doaj   +1 more source

Toll-like receptor 4-mediated endoplasmic reticulum stress induces intestinal paneth cell damage in mice following CLP-induced sepsis

Scientific Reports, 2022
A marked elevation of TLR4 was observed in various organs of septic mice. The mechanism of TLR4 in intestinal epithelial cell damage in sepsis remains unclear.
Yijie Wang, Dapeng Zhang, Congxin Li, Xue Wu, Chen He, Xiaolin Zhu, Haiyan Zhao, Lingjie Mu   +7 more
doaj   +1 more source

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

The non-canonical mechanism of ER stress-mediated progression of prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing.
Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli, Thomas S. Payne, Robert Powers, Alexander Y. Lushnikov, Amanda J. Macke, Armen Petrosyan   +20 more
doaj   +1 more source

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

ER Stress Activates the TOR Pathway through Atf6

Journal of Molecular Signaling, 2018
Cellular signaling pathways are often interconnected. They accurately and efficiently regulate essential cell functions such as protein synthesis, cell growth, and survival. The target of rapamycin (TOR) signaling pathway and the endoplasmic reticulum (ER) stress response pathway regulate similar cellular processes.
Dylan Allen, Jin Seo
openaire   +4 more sources

Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke

Frontiers in Cellular Neuroscience, 2022
Objective: Brain ischemia leads to the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) lumen and consequently, ER stress. To help cells restore ER function, a series of adaptive stress response pathways, collectively termed the unfolded protein response (UPR), are activated.
Xuan Li, Ran Li, Liping Lu, Ashis Dhar, Huaxin Sheng, Wei Yang   +5 more
openaire   +3 more sources

The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi [PDF]

Journal of Biological Chemistry, 2002
ATF6 is an endoplasmic reticulum (ER) transmembrane transcription factor that is activated by the ER stress/unfolded protein response by cleavage of its N-terminal half from the membrane. We find that ER stress induces ATF6 to move from the ER to the Golgi, where it is cut in its luminal domain by site 1 protease.
Xi, Chen, Jingshi, Shen, Ron, Prywes
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source