Results 71 to 80 of about 28,246 (239)

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases

, 2019
Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip)
Wei-Chieh Jerry, Chiang, Heike, Kroeger, Lulu, Chea, Jonathan H, Lin   +3 more
openaire   +3 more sources

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6. [PDF]

, 2015
Background MicroRNA (miRNA) and messenger RNA (mRNA) expression differs in cystic fibrosis (CF) versus non-CF bronchial epithelium. Here, the role of miRNA in basal regulation of the transcription factor ATF6 was investigated in bronchial epithelial ...
Agrawal, Raman, Greene, Catherine M, Mall, Marcus A, McElvaney, Noel G, Oglesby, Irene K   +4 more
core   +2 more sources

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

Cell Reports, 2013
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6.
Matthew D. Shoulders, Lisa M. Ryno, Joseph C. Genereux, James J. Moresco, Patricia G. Tu, Chunlei Wu, John R. Yates, III, Andrew I. Su, Jeffery W. Kelly, R. Luke Wiseman   +9 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in dutch Caucasians [PDF]

, 2007
Context: Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians ...
Ayoubi, Torik A., Boer, Jolanda M. A., de Bruin, Tjerk W. A., Feskens, Edith J. M., Hofker, Martin H., Meex, Steven J. R., Schalkwijk, Casper G., Stehouwer, Coen D. A., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., van Vliet-Ostaptchouk, Jana V., Vermeulen, Vicky M. M. -J., Vlietinck, Robert   +12 more
core   +2 more sources

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

ATF6 and Thrombospondin 4 [PDF]

Circulation Research, 2013
Thrombospondins are secreted, nonstructural, extracellular matrix proteins that are upregulated in the heart and other tissues in response to ischemic injury and pathology. Roles for thrombospondins after they are secreted have been examined in a variety of disease models, including myocardial pathology. However, a recent study published in the journal
Shirin, Doroudgar, Christopher C, Glembotski   +1 more
openaire   +2 more sources

ATF6 activation promotes tumorigenesis and drug resistance in diffuse large B-cell lymphoma (DLBCL) by regulating the mTOR/S6K signaling pathway

Discover Oncology
This study analyzes the expression and functional role of activating transcription factor 6 (ATF6) in diffuse large B-cell lymphoma (DLBCL) and its effects on disease progression.
Shuang Su, Lili Wu, Chen Huang, Cuiying He, Lianjing Wang, Weijing Li, Wei Liu, Lihong Liu   +7 more
doaj   +1 more source

Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients

BMC Gastroenterology, 2017
Background Recently, it is reported that asparagine synthetase (ASNS) is an independent predictor of surgical survival in hepatocellular carcinoma (HCC) patients.
Wei Li, Chengwei Dong
doaj   +1 more source