Results 81 to 90 of about 21,147 (240)

Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response [PDF]

Journal of Biological Chemistry, 2009
Stresses that perturb the folding of nascent endoplasmic reticulum (ER) proteins activate the ER stress response. Upon ER stress, ER-associated ATF6 is cleaved; the resulting active cytosolic fragment of ATF6 translocates to the nucleus, binds to ER stress response elements (ERSEs), and induces genes, including the ER-targeted chaperone, GRP78.
Shirin, Doroudgar, Donna J, Thuerauf, Marie C, Marcinko, Peter J, Belmont, Christopher C, Glembotski   +4 more
openaire   +2 more sources

Atf6 is required for alcoholic steatosis.

, 2014
A: qPCR analysis of UPR sensors atf6, perk, ire1a, and atf4 in the livers of control (EtOH-) and 350 mM ethanol-treated (EtOH+) larvae. dCt values were calculated by normalization to rpp0.
Ravi Sachidanandam (96327), Ana M. Vacaru (569514), Orkhontuya Tsedensodnom (154217), Kirsten C. Sadler (184980), Christoph Buettner (371512), Deanna L. Howarth (569512), Claudia Lindtner (569513), Taisa Vasilkova (569515)   +7 more
core   +1 more source

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

eLife, 2020
The unfolded protein response (UPR) is a cellular homeostatic circuit regulating protein synthesis and processing in the ER by three ER-to-nucleus signaling pathways. One pathway is triggered by the inositol-requiring enzyme 1 (IRE1), which splices the X-
Florian Hinte, Eelco van Anken, Boaz Tirosh, Wolfram Brune   +3 more
doaj   +1 more source

Berberine alleviates pyroptosis of retinal ganglion cells in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source

The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts

, 2020
Activating transcription factor-6 α (ATF6) is one of the three main sensors and effectors of the endoplasmic reticulum (ER) stress response and, as such, it is critical for protecting the heart and other tissues from a variety of environmental ...
Azizi, Blackwood, Stauffer, Kaufman, Glembotski   +4 more
core   +1 more source

Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells

Journal of International Medical Research, 2020
Objective Titanium oxide (TiO 2 ) acts as a photosensitizer in photodynamic therapy by mediating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress.
Zhiwang Li, Jingliang He, Bowei Li, Jinqian Zhang, Ke He, Xiaopeng Duan, Rui Huang, Zuguang Wu, Guoan Xiang   +8 more
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Characterization of Retinal Structure in ATF6-Associated Achromatopsia [PDF]

, 2019
Purpose: Mutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be identified, though thorough phenotyping of this genetic subtype is lacking. Here, we sought to
Singh, N, Patterson, EJ, Kane, T, Carroll, J, Tsang, SH, Georgiou, M, Lin, JH, Hartnett, ME, Mastey, RR, Vincent, A, Langlo, CS, Moore, AT, Michaelides, M, Young, MP, Kalitzeos, A, Héon, E, Kohl, S   +16 more
core  

Impact of ATF6 deletion on the embryonic brain development

iScience
Although the unfolded protein response (UPR) is activated during brain development, its roles remain unclear. Here, we report that deletion of activating transcription factor 6 (ATF6), consisting of ATF6α and ATF6β, in the developing brain caused microcephaly and neonatal death in mice.
Loc Dinh Nguyen, Ly Huong Nguyen, Dat Xuan Dao, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Takashi Tamatani, Hiroshi Kawasaki, Yohei Shinmyo, Kenta Onoue, Shigenobu Yonemura, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Kazutoshi Mori, Osamu Hori   +15 more
openaire   +4 more sources

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases

, 2019
Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip)
Wei-Chieh Jerry, Chiang, Heike, Kroeger, Lulu, Chea, Jonathan H, Lin   +3 more
openaire   +3 more sources