Results 101 to 110 of about 21,147 (240)

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Neurobiology of Disease, 2001
Presenilin (PS) proteins facilitate endoproteolysis of selected type I transmembrane proteins such as the Alzheimer's disease (AD) associated β-Amyloid precursor protein (βAPP) and Notch.
Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass   +4 more
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, EarlyView.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Activation of ATF6 by G572R-hERG and E637K-hERG.

, 2013
HEK293 cells were transfected with WT-hERG, G572R-hERG or E637K-hERG plasmid. Cell lysates were subjected to Western blotting with anti-ATF6 antibody. The cleaved, activated form of ATF6 at 50 kDa is only detected in G572R-hERG and E637K-hERG expressing ...
Huan Huan Sun (335949), Di Li (335947), Ningsheng Liu (335951), Xiaoyan Huang (112885), Jiangfang Lian (112879), Jianqing Zhou (112889), Ying Wang (11406), Haiyan Mao (335948), Xi Yang (112884)   +8 more
core   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein [PDF]

, 2019
Activation of the unfolded protein response (UPR)-associated transcription factor ATF6 has emerged as a promising strategy to reduce the secretion and subsequent toxic aggregation of destabilized, amyloidogenic proteins implicated in systemic amyloid ...
Joseph C. Genereux, R. Luke Wiseman, Rius, Bibiana, Bianca Nguyen, Kelly, Jeffery W, Jeffery W. Kelly, Bibiana Rius, Nguyen, Bianca, Genereux, Joseph C, Plate, Lars, Wiseman, R Luke, Lars Plate   +11 more
core   +1 more source

Immunoblot of SupT1^DAX cells shows that the XBP1s and ATF6 pathways are successfully and differentially induced.

, 2022
Representative immunoblot image showing specific upregulation of XBP1s (Sec24D) and ATF6 (BiP) protein targets in SupT1DAX cells upon vehicle treatment (basal), dox treatment (+XBP1s), TMP treatment (+ATF6), and co-treatment of dox and TMP (+XBP1s/+ATF6).
Yu Meng Zhang (12107344), Tiffani Hui (12107338), Yu-Shan Lin (519689), Anna I. Ponomarenko (5753729), Matthew D. Shoulders (1323849), Jessica E. Patrick (12107335), Samuel J. Hendel (6083825), Emmanuel E. Nekongo (1433023), C. Brandon Ogbunugafor (7207766), Angela M. Phillips (5753726), Rebecca M. Sebastian (12107341), Jimin Yoon (9646685), Vincent L. Butty (8957051)   +12 more
core   +1 more source

MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway

Molecular Medicine
Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated.
Guozhi Yan, Rongrong Song, Jieyu Zhang, Zhihao Li, Zhantao Lu, Zijian Liu, Xiaokang Zeng, Jie Yao   +7 more
doaj   +1 more source

The Effects of IRE1, ATF6, and PERK Signaling on adRP-Linked Rhodopsins [PDF]

, 2014
Many mutations in rhodopsin gene linked to retinitis pigmentosa (RP) cause rhodopsin misfolding. Rod photoreceptor cells expressing misfolded rhodopsin eventually die. Identifying mechanisms to prevent rhodopsin misfolding or to remove irreparably misfolded rhodopsin could provide new therapeutic strategies.
Jerry Chiang, Wei-Chieh, Lin, Jonathan H
openaire   +4 more sources