Results 121 to 130 of about 28,246 (239)

Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease [PDF]

, 2016
Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood.
Alberto Rábano, Alicia De la Cruz, Angela Prieto, Beal, Benjamini, Britt Mellström, Carmen Valenzuela, Diego Villar, Elena Higueras, Halliday, Hongyu Zhang, Javier Morón-Oset, Jia-Yi Li, José R. Naranjo, Juan C. Oliveros, Juan Casado-Vela, Marta Gutierrez-Rodriguez, María D. Arrabal, Miller, Moreno, Okada, Paz González, Pilar Cercós, Rivas, Sidrauski, Tabas-Madrid, Teresa González, Wang, Wu, Xose M. Dopazo   +29 more
core   +2 more sources

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription

International Journal of Oral Science
Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application.
Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan   +10 more
doaj   +1 more source

Lycium barbarum polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism

Acta Biochimica et Biophysica Sinica
Lipid droplets (LDs) are dynamic organelles that store neutral lipids and are closely linked to obesity. Previous studies have suggested that Lycium barbarum polysaccharide (LBP) supplements can ameliorate obesity, but the underlying
Zhou Rui, Liu Yajing, Hu Weiqian, Yang Jing, Lin Bing, Zhang Zhentian, Chen Mingyan, Yi Jingwen, Zhu Cuifeng   +8 more
doaj   +1 more source

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. [PDF]

, 2017
Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription.
Ang, Kenny, Arkin, Michelle, Baeyens, Luc, Chen, Steven, Choe, Justin, Gambhir Chopra, Deeksha, German, Michael S, Hennings, Thomas G, Ku, Gregory M, McManus, Michael T, Pappalardo, Zachary, Richards, Hunter, Yang, Katherine   +12 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

Neurobiology of Disease, 2015
The unfolded protein response (UPR) monitors the folding environment within the endoplasmic reticulum (ER). Accumulation of misfolded proteins within the ER activates the UPR resulting in the execution of adaptive or non-adaptive signaling pathways.
Joel J. Credle, Patrick A. Forcelli, Michael Delannoy, Adam W. Oaks, Eva Permaul, Deborah L. Berry, Valeriy Duka, Jonathan Wills, Anita Sidhu   +8 more
doaj   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Cell Reports, 2016
Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes. In obesity, activation of calcium/calmodulin-dependent protein kinase II (CaMKII) in hepatocytes suppresses ATF6, which triggers a PERK-ATF4-TRB3 pathway that disrupts insulin
Lale Ozcan, Devram S. Ghorpade, Ze Zheng, Jane Cristina de Souza, Ke Chen, Marc Bessler, Melissa Bagloo, Beth Schrope, Richard Pestell, Ira Tabas   +9 more
doaj   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source