British Journal of Pharmacology, EarlyView.TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva +10 more
wiley +1 more source
Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death. [PDF]
, 2019 学位記番号 ...
Shibusawa, Ryo +2 more
core
Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells [PDF]
, 2010 AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in ...
Andreozzi, F +12 more
core +1 more source
Cell Proliferation, EarlyView.The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao +6 more
wiley +1 more source
MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway
Molecular MedicineRheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated.
Guozhi Yan +7 more
doaj +1 more source
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH [PDF]
, 2005 Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least two separate amplicons within this ...
Kresse, Stine H +7 more
core +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome
The Journal of Clinical InvestigationActivating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR) and is important for ER function and protein homeostasis in metazoan cells.
Eun-Jin Lee +9 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-
Tino Prell +10 more
doaj +1 more source
Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway. [PDF]
, 2015 Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC).
Geng, Wei +9 more
core +1 more source