Results 61 to 70 of about 21,147 (240)

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Alterations of EDEM1 functions enhance ATF6 pro-survival signaling

, 2018
International audienceActivating transcription factor 6 alpha (referred to as ATF6 hereafter) is an endoplasmic reticulum (ER)-resident glycoprotein and one of the three sensors of the unfolded protein response (UPR).
Papaioannou, Alexandra, Alexandra Papaioannou, Laure Saas, Pineau, Raphael, Saas, Laure, Pluquet, Olivier, Florence Jouan, Arisa Higa, Olivier Pluquet, Raphael Pineau, Jouan, Florence, Chevet, Eric, Jegou, Gwenaele, Gwénaële Jégou, Higa, Arisa, Tony Avril, Avril, Tony, Eric Chevet   +17 more
core   +1 more source

Data_Sheet_1_Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.PDF

, 2022
Objective: Brain ischemia leads to the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) lumen and consequently, ER stress. To help cells restore ER function, a series of adaptive stress response pathways, collectively termed ...
Liping Lu (533560), Ashis Dhar (11560543), Xuan Li (137217), Wei Yang (109917), Ran Li (57928), Huaxin Sheng (2118295)   +5 more
core   +1 more source

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

eLife, 2016
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation.
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly   +17 more
doaj   +1 more source

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

Cells, 2022
The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid diseases.
Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ethan M. Smith-Cohen, Julia M. D. Grandjean, Jeffery W. Kelly, Joseph C. Genereux, R. Luke Wiseman   +6 more
doaj   +1 more source

ATF6 and Thrombospondin 4 [PDF]

Circulation Research, 2013
Thrombospondins are secreted, nonstructural, extracellular matrix proteins that are upregulated in the heart and other tissues in response to ischemic injury and pathology. Roles for thrombospondins after they are secreted have been examined in a variety of disease models, including myocardial pathology. However, a recent study published in the journal
Shirin, Doroudgar, Christopher C, Glembotski   +1 more
openaire   +2 more sources

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

‐binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6 [PDF]

, 2021
Sorcin is a calcium-binding protein involved in maintaining endoplasmic reticulum (ER) Ca2+ stores. We have previously shown that overexpressing sorcin under the rat insulin promoter was protective against high-fat diet-induced pancreatic beta-cell ...
Kalvakolanu, Dhananjaya, Tian Gao, Steven Z. Parks, Ayathamattam, Joseph, Pauline L. Chabosseau, Valdivia, Hector H, Parks, Steven Z, Gao, Tian, Rutter, Guy A, Natalia Jimenez Awuapura, Guy A. Rutter, Awuapura, Natalia Jimenez, Chabosseau, Pauline L, Joseph Ayathamattam, Héctor H. Valdivia, Isabelle Leclerc, Dhananjaya V. Kalvakolanu, Leclerc, Isabelle, Nakatogawa, Hitoshi   +18 more
core   +1 more source

ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress

Cell Death Discovery, 2022
Colon cancer represents one of the most common and aggressive cancers in its advanced state. Among the most innovative anti-cancer approaches, the manipulation of UPR is a promising one, effective also against cancers carrying dysfunctional p53 ...
Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Livia Di Renzo, Gabriella D’Orazi, Mara Cirone   +6 more
doaj   +1 more source