Results 41 to 50 of about 21,147 (240)

The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi [PDF]

Journal of Biological Chemistry, 2002
ATF6 is an endoplasmic reticulum (ER) transmembrane transcription factor that is activated by the ER stress/unfolded protein response by cleavage of its N-terminal half from the membrane. We find that ER stress induces ATF6 to move from the ER to the Golgi, where it is cut in its luminal domain by site 1 protease.
Xi, Chen, Jingshi, Shen, Ron, Prywes
openaire   +2 more sources

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation,
Yuntian Shen, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng, Wei Yang   +6 more
doaj   +1 more source

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

eLife, 2018
Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases.
Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffery W Kelly   +6 more
doaj   +1 more source

Macular maldevelopment inATF6-mediated retinal dysfunction [PDF]

Ophthalmic Genetics, 2019
Background: Achromatopsia has been previously associated with mutations in the ATF6 gene. Rod-monochromatism, foveal hypoplasia, and disruption of the subfoveal photoreceptor layer are described as phenotypical features. We report detailed structural and electrophysiological assessment of two patients from two families, one manifesting severe macular ...
Markus Ritter, Gavin Arno, Rola Ba-Abbad, Graham E. Holder, Andrew R. Webster   +4 more
openaire   +3 more sources

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Pajukanta, P., Hofker, M.H., Glembotski, C.C., Laakso, K., Meex, S.J., Weissglas-Volkov, D., Kallen, C.J., Thuerauf, D.J., Sinsheimer, J.S., Vlietinck, R., Kuusisto, J., Schalkwijk, C.G., Ayoubi, T.A., Wouters, B.G., Taskinen, M.R., Feskens, E.J.M., Greevenbroek, M.M., Bruin, T.W., Stehouwer, C.D., Heldens, J.   +19 more
core   +1 more source

Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier

Cancer Biology & Medicine
Objective: Migrasomes, an emerging class of migration-facilitating membranous extracellular vesicles, remain largely uncharted in the intricate landscape of tumor metastasis.
Song Wang, Guohao Gu, Xinmiao Xian, Jun Li, Di Zhang, Jianran Guo, Anqi Zhang, Shen Chen, Dong Yan, Bingwu Yang, Meng An, Wei Zhang, Bo Fu   +12 more
doaj   +1 more source

EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4

, 2009
We have isolated the rat ortholog of EFP1 (EF-hand binding protein 1) as a novel interaction partner of the pro-apoptotic protein Par-4 (prostate apoptosis response-4).
Maertens, Barbara, Koplin, Ansgar, Appel, Sarah, Preuss, Ute, Vetterkind, Susanne, Boosen, Meike   +5 more
core   +1 more source

Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer

结直肠肛门外科
[Objectives] To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver metastasis after laparoscopic radical resection of colorectal cancer.
Wang Yi, Zhang Dan, You Xiao
doaj   +1 more source

Achromatopsia mutations target sequential steps of ATF6 activation [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance The unfolded protein response regulator activating transcription factor 6 ( ATF6 ) was recently identified as a novel genetic cause of the cone photoreceptor disease achromatopsia. ATF6 upregulates genes that help cells cope with endoplasmic reticulum stress.
Wei-Chieh, Chiang, Priscilla, Chan, Bernd, Wissinger, Ajoy, Vincent, Anna, Skorczyk-Werner, Maciej R, Krawczyński, Randal J, Kaufman, Stephen H, Tsang, Elise, Héon, Susanne, Kohl, Jonathan H, Lin   +10 more
openaire   +2 more sources

Overlapping and differential functions of ATF6 alpha versus ATF6 beta in the mouse heart

, 2019
Hemodynamic stress on the mammalian heart results in compensatory hypertrophy and activation of the unfolded protein response through activating transcription factor 6 alpha (ATF6 alpha) in cardiac myocytes, but the roles of ATF6 alpha or the related ...
Khalil, Hadi, Lynch, Jeffrey M., Molkentin, Jeffery D., Prasad, Vikram, Correll, Robert N., Grimes, Kelly M.   +5 more
core   +1 more source