Results 21 to 30 of about 28,246 (239)

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. [PDF]

PLoS Genetics, 2014
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR).
Deanna L Howarth, Claudia Lindtner, Ana M Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C Sadler   +7 more
doaj   +1 more source

Interaction of ATF6 and serum response factor [PDF]

Molecular and Cellular Biology, 1997
Serum response factor (SRF) is a transcription factor which binds to the serum response element (SRE) in the c-fos promoter. It is required for regulated expression of the c-fos gene as well as other immediate-early genes and some tissue-specific genes. To better understand the regulation of SRF, we used a yeast interaction assay to screen a human HeLa
C, Zhu, F E, Johansen, R, Prywes
openaire   +2 more sources

Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]

Medicinski Podmladak
Endoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka, Stanojević Željka   +1 more
doaj   +1 more source

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

Frontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou, Simin Zhou, Simin Zhou, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Pei Huang, Pei Huang, Pei Huang, Bin Xiang, Bin Xiang, Bin Xiang, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Huaping Dong, Huaping Dong, Huaping Dong, Gang Zhang, Gang Zhang, Gang Zhang, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +26 more
doaj   +1 more source

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels [PDF]

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Ayoubi, T.A., Bruin, T.W., Feskens, E.J.M., Glembotski, C.C., Greevenbroek, M.M., Heldens, J., Hofker, M.H., Kallen, C.J., Kuusisto, J., Laakso, K., Meex, S.J., Pajukanta, P., Schalkwijk, C.G., Sinsheimer, J.S., Stehouwer, C.D., Taskinen, M.R., Thuerauf, D.J., Vlietinck, R., Weissglas-Volkov, D., Wouters, B.G.   +19 more
core   +1 more source

Achromatopsia mutations target sequential steps of ATF6 activation [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance The unfolded protein response regulator activating transcription factor 6 ( ATF6 ) was recently identified as a novel genetic cause of the cone photoreceptor disease achromatopsia. ATF6 upregulates genes that help cells cope with endoplasmic reticulum stress.
Wei-Chieh, Chiang, Priscilla, Chan, Bernd, Wissinger, Ajoy, Vincent, Anna, Skorczyk-Werner, Maciej R, Krawczyński, Randal J, Kaufman, Stephen H, Tsang, Elise, Héon, Susanne, Kohl, Jonathan H, Lin   +10 more
openaire   +2 more sources

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources

Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). [PDF]

, 2014
Selenium (Se) is an essential micronutrient that can cause embryotoxicty at levels 7-30 times above essential concentrations. Exposure to hypersaline conditions and 50 μM selenomethionine (SeMet) decreased embryo hatch and depleted glutathione in ...
Kupsco, Allison, Schlenk, Daniel
core   +1 more source

Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]

, 2016
Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan, Diaz-Salazar, Carlos, Eltis, Lindsay D, Liu, Jie, Otani, Hiroshi, Seghezzi, Nicolas   +5 more
core   +2 more sources