Results 11 to 20 of about 28,246 (239)

Mineral trioxide aggregate induces osteoblastogenesis via Atf6

Bone Reports, 2015
Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells.
Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, Yasumasa Kato   +5 more
doaj   +3 more sources

ATF6 as a Nodal Regulator of Proteostasis in the Heart [PDF]

Frontiers in Physiology, 2020
Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include protein synthesis, folding, trafficking,
Christopher C. Glembotski, Adrian Arrieta, Erik A. Blackwood, Winston T. Stauffer   +3 more
doaj   +3 more sources

Characterization of Retinal Structure in ATF6-Associated Achromatopsia. [PDF]

Investigative Opthalmology & Visual Science, 2019
PurposeMutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be identified, though thorough phenotyping of this genetic subtype is lacking.
Carroll, Joseph, Georgiou, Michalis, Hartnett, M Elizabeth, Héon, Elise, Kalitzeos, Angelos, Kane, Thomas, Kohl, Susanne, Langlo, Christopher S, Lin, Jonathan H, Mastey, Rebecca R, Michaelides, Michel, Moore, Anthony T, Patterson, Emily J, Singh, Navjit, Tsang, Stephen H, Vincent, Ajoy, Young, Marielle P   +16 more
core   +7 more sources

A lifetime of stress: ATF6 in development and homeostasis [PDF]

Journal of Biomedical Science, 2018
Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors.
Robert F. Hillary, Una FitzGerald
doaj   +4 more sources

Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement

Pharmaceuticals
Background/Objectives: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance ...
Saikat Fakir, Nektarios Barabutis
doaj   +3 more sources

BiP Binding Keeps ATF6 at Bay [PDF]

Developmental Cell, 2002
A study by, in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides ...
Sommer, Thomas, Jarosch, Ernst
openaire   +2 more sources

Multiexon deletion alleles of ATF6 linked to achromatopsia [PDF]

JCI Insight, 2020
Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and photoaversion starting from infancy; furthermore, ACHM is associated with bilateral foveal hypoplasia and absent or severely reduced cone photoreceptor function on electroretinography.
Eun-Jin Lee, Wei-Chieh Jerry Chiang, Heike Kroeger, Chloe Xiaoke Bi, Daniel L. Chao, Dorota Skowronska-Krawczyk, Rebecca R. Mastey, Stephen H. Tsang, Leon Chea, Kyle Kim, Scott R. Lambert, Julia M.D. Grandjean, Britta Baumann, Isabelle Audo, Susanne Kohl, Anthony T. Moore, R. Luke Wiseman, Joseph Carroll, Jonathan H. Lin   +18 more
openaire   +4 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Macular maldevelopment inATF6-mediated retinal dysfunction [PDF]

Ophthalmic Genetics, 2019
Background: Achromatopsia has been previously associated with mutations in the ATF6 gene. Rod-monochromatism, foveal hypoplasia, and disruption of the subfoveal photoreceptor layer are described as phenotypical features. We report detailed structural and electrophysiological assessment of two patients from two families, one manifesting severe macular ...
Markus Ritter, Gavin Arno, Rola Ba-Abbad, Graham E. Holder, Andrew R. Webster   +4 more
openaire   +3 more sources

Mutation of ATF6 causes autosomal recessive achromatopsia [PDF]

Human Genetics, 2015
Achromatopsia (ACHM) is an early-onset retinal dystrophy characterized by photophobia, nystagmus, color blindness and severely reduced visual acuity. Currently mutations in five genes CNGA3, CNGB3, GNAT2, PDE6C and PDE6H have been implicated in ACHM. We performed homozygosity mapping and linkage analysis in a consanguineous Pakistani ACHM family and ...
Muhammad Ansar, Suzanne M. Leal, Huma Qureshi, Fareeha Zulfiqar, Kwanghyuk Lee, Naeem Mahmood Ashraf, Ehsan Ullah, Xin Wang, Sundus Sajid, Falak Sher Khan, Muhammad Aminuddin, Joshua D. Smith, Jay Shendure, Michael J. Bamshad, Deborah A. Nickerson, Abdul Hameed, Saima Riazuddin, Zubair M. Ahmed, Wasim Ahmad, Suzanne M. Leal   +19 more
openaire   +2 more sources