Results 61 to 70 of about 4,243,823 (319)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

THE ACTIVE UNIVERSE [PDF]

International Journal of Bifurcation and Chaos, 2011
Active motion is a concept in complex systems theory and was successfully applied to various problems in nonlinear dynamics. Explicit studies for gravitational potentials were missing so far. We interpret the Friedmann equations with cosmological constant as a dynamical system, which can be made "active" in a straightforward way.
Glück, Alexander, Hüffel, Helmuth, Ilijic, Sasa, Kelnhofer, Gerald   +3 more
openaire   +4 more sources

Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling

Nature Communications
Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs ubiquitous in pharmaceutically ...
Gabriel M. F. Batista, Ruth Ebenbauer, Craig Day, Jonas Bergare, Karoline T. Neumann, Kathrin H. Hopmann, Charles S. Elmore, Alonso Rosas-Hernández, Troels Skrydstrup   +8 more
doaj   +1 more source

The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

Scientific Reports, 2022
Evidence from previous studies suggests a protective effect of metformin in patients with colorectal cancer (CRC). The aim of this study was to examine the associations between metformin use and overall survival (OS) and disease-free survival (DFS) in ...
Zeinab Tarhini, Kamelia Manceur, Julien Magne, Muriel Mathonnet, Jeremy Jost, Niki Christou   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]

, 2010
Apicomplexan parasites within the genus <i>Theileria</i> have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte.
Weir, W., Hermann, P., McKellar, S., Dobbelaere, D., Dobbelaere, Dirk,, Schmuckli-Maurer, J., Pillai, S., Shiels, B., Kinnaird, J.   +8 more
core   +1 more source

Active learning enabled activity recognition [PDF]

Pervasive and Mobile Computing, 2016
© 2016 IEEE, 2016 IEEE International Conference on Pervasive Computing and Communications (PerCom)
H. M. Sajjad Hossain, Nirmalya Roy, Md Abdullah Al Hafiz Khan   +2 more
openaire   +1 more source

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

Nature Communications
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour   +17 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Activation-Coupled Membrane Type 1 Matrix Metalloproteinase Membrane Trafficking.

, 2007
The transmembrane collagenase MT1-MMP (membrane-type 1 matrix metalloproteinase),also known as MMP-14,has a critical function both in normal development and in cancer progression,and is subject to extensive controls at the post-translational level which ...
Guy S. Salvesen (182933), Sharon Stack (17332237), Hidayatullah G. Munshi (11437026), Rafael Fridman (320046), Scott J. Snipas (769755), Yi I. Wu (1901566)   +5 more
core   +1 more source