Results 61 to 70 of about 2,043,262 (319)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Cauchy activation function and XNet

Neural Networks
We have developed a novel activation function, named the Cauchy Activation Function. This function is derived from the Cauchy Integral Theorem in complex analysis and is specifically tailored for problems requiring high precision. This innovation has led to the creation of a new class of neural networks, which we call (Comple)XNet, or simply XNet.
Li, Xin, Xia, Zhihong, Zhang, Hongkun
openaire   +3 more sources

A Neural Network Approximation Based on a Parametric Sigmoidal Function

Mathematics, 2019
It is well known that feed-forward neural networks can be used for approximation to functions based on an appropriate activation function. In this paper, employing a new sigmoidal function with a parameter for an activation function, we consider a ...
Beong In Yun
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Pavement Defect Detection Algorithm Based on Improved YOLOv7 Complex Background

IEEE Access
The detection of pavement diseases is an important and basic link in the road maintenance process. Many methods based on deep learning have been applied.
Zou Chunlong, Huang Peile, Wang Shenghuai, Wang Chen, Wang Hongxia   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Comparison of Activation Functions in Convolutional Neural Network for Poisson Noisy Image Classification

Emerging Science Journal
Deep learning, specifically the Convolutional Neural Network (CNN), has been a significant technology tool for image processing and human health. CNNs, which mimic the working principles of the human brain, can learn robust representations of images ...
Khang Wen Goh, Sugiyarto Surono, M. Y. Firza Afiatin, K. Robiatul Mahmudah, Nursyiva Irsalinda, Mesith Chaimanee, Choo Wou Onn   +6 more
doaj   +1 more source

Dual Activation Function-Based Extreme Learning Machine (ELM) for Estimating Grapevine Berry Yield and Quality

Remote Sensing, 2019
Reliable assessment of grapevine productivity is a destructive and time-consuming process. In addition, the mixed effects of grapevine water status and scion-rootstock interactions on grapevine productivity are not always linear.
Matthew Maimaitiyiming, Vasit Sagan, Paheding Sidike, Misha T. Kwasniewski   +3 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source