Results 231 to 240 of about 338,751 (320)

A medicinal chemistry perspective on SIRT3 modulators in disease treatment. [PDF]

RSC Med Chem
Li Y, Bao Y, Cui Y, Zhang J, Wang M.
europepmc   +1 more source

H2S Inhibits Hyperglycemia-Induced Intrarenal Renin-Angiotensin System Activation via Attenuation of Reactive Oxygen Species Generation

, 2013
Hong Xue, Ping Yuan, Jun Ni, Chen Li, Decui Shao, Jia Liu, Yang Shen, Zhen Wang, Li Zhou, Wei Zhang, Yü Huang, Yu Chen, Rui Wang, Limin Lü   +13 more
openalex   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The joint-local renin-angiotensin system in rheumatoid arthritis and osteoarthritis: mechanistic evidence, disease-specific patterns, and translational perspectives. [PDF]

Rheumatol Int
Bilgin E, Haznedaroğlu İC.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

From inhibition to regulation: serpins in health and disease. [PDF]

Biomed J
Kattner AA.
europepmc   +1 more source

A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors

Alireza Rezvani-Sharif, Hadi Lioe, Steven Dower, Matthias Pelzing, Con Panousis, Dalton J. E. Harvie, Ineke Muir   +6 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Fibrinolysis-unrelated functions of the plasminogen/plasmin system: A gateway to successful parasitism? [PDF]

Curr Res Parasitol Vector Borne Dis
Serrat J, Siles-Lucas M, González-Miguel J.   +2 more
europepmc   +1 more source