Results 101 to 110 of about 1,063,100 (311)
Yeast Crf1p: An activator in need is an activator indeed
, 2022 Ribosome biogenesis is an energetically costly process, and tight regulation is required for stoichiometric balance between components. This requires coordination of RNA polymerases I, II, and III.
Kumar, Sanjay +5 more
core +1 more source
Marine Drugs, 2019 The γ-carbonic anhydrases (CAs, EC 4.2.1.1) present in the Antarctic marine bacteria Pseudoalteromonas haloplanktis and Colwellia psychrerythraea, herein referred to as PhaCA and CpsCA, respectively, were investigated for their activation with a ...
Andrea Angeli +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Activator-Mediator binding regulates Mediator-cofactor interactions
, 2010 The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps all protein-coding genes. Activator binding triggers major structural shifts within Mediator, suggesting a straightforward means to spatially and temporally regulate ...
Christopher C. Ebmeier, Dylan J. Taatjes
core +1 more source
Dual regulation of autophagy: paradoxical effects on tumor angiogenesis
Frontiers in Cell and Developmental BiologyAutophagy plays a critical role in dynamic cell growth under different environmental conditions and maintains cellular homeostasis and cell viability in response to different cellular injuries, especially in tumor angiogenesis, where there is a ...
Shanshan Xiang +6 more
doaj +1 more source
On Putting the Active Back into Activism
New Formations, 2010 This paper addresses a paradox: how to engage in affirmative politics, which entails the production of social horizons of hope, while at the same time doing critical theory, which means resisting the present. Drawing on the neo-vitalism of Deleuze, with reference to Nietzsche and Spinoza, the article argues in favour of an affirmative ethics: defined ...
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator-5
, 2011 Copyright information:Taken from "Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator"http://www.biomedcentral.com/1471-2199/8/106BMC Molecular Biology 2007;8():106-106.Published online 16 Nov 2007PMCID:PMC2233640 ...
Winnie Eskild (68339) +8 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source