Results 91 to 100 of about 1,301,037 (308)

Structures, substrates, and regulators of mammalian Sirtuins – opportunities and challenges for drug development

Frontiers in Pharmacology, 2012
Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1-7, which differ in their substrate specificities and subcellular localizations.
Sebastien eMoniot, Michael eWeyand, Clemens eSteegborn   +2 more
doaj   +1 more source

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]

, 2016
Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F., Lowes, D. A., McCreath, G., Scullion, M. M. F., Webster, N. R.   +4 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Evaluatıon Of The Changes Occurıng In The Vertıcal Dırectıon Of The Face In Cases Treated Wıth Actıvator + Occıpıtal Headgear Combınatıon

Turkish Journal of Orthodontics, 1989
The aim of this study was to evaluate the vertical skeletal and dentoalveolar changes in the Class II Division 1 cases treated with the activator + occipital headgear combination.
Zahir Altuğ, Zehra Bayazıt, Haluk İşeri, Hakan Gögen   +3 more
doaj   +1 more source

Influence of polymerisation conditions on the properties of polymer/clay nanocomposite hydrogels [PDF]

, 2013
Free-radical polymerisation of acrylamide derivatives in the presence of exfoliated clay platelets has recently emerged as a new technique for the synthesis of strong and tough nanocomposite hydrogels (NCHs) with a unique hybrid organic/inorganic network
Abdurrahmanoglu, Anseth, Bera, Calvet, Carlsson, Dokter, Feng, Fengge Gao, Gao, Gao, Giraldo, Giz, Gong, Gu, Haraguchi, Haraguchi, Haraguchi, Haraguchi, Haraguchi, Hu, Ito, Kabiri, Kalfus, Kulicke, Liu, Martin Bencsik, Okay, Rinat Nigmatullin, Sakai, Schexnailder, Solomon, Solomon, Tamagawa, Tanaka, Wang, Wu, Xu   +36 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Sımple Orthodontıc Approach In Late Permanent Dentıtıon For Class Iı/1 Cases: Removable Herbst Applıance

Turkish Journal of Orthodontics, 1996
The disadvantages of fixed Herbst appliance, such as hgiene problems, limitations of mandibular functional movements, etc., leads certain authors to design a new removable appliance having same mechanic principals.
Eray Erdoğan
doaj   +1 more source

Intrinsic limits to gene regulation by global crosstalk [PDF]

, 2016
Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF-DNA interactions
Barton, Nicholas H., Friedlander, Tamar, Guet, Călin C., Prizak, Roshan, Tkačik, Gašper   +4 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source